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Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial

Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cd72

Uniprot NO.

P21855

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in B-cell proliferation and differentiation.

Gene References into Functions

CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP. PMID:27810925
CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha. PMID:25239131
These results strongly suggest that the Cd72(c) is a crucial modifier gene that regulates Fas(lpr)-induced autoimmune disease due to its reduced activity of B cell signal regulation. PMID:23616572
Cd72 polymorphism affects susceptibility to lupus phenotypes. PMID:23365086
Inhibitory coreceptors CD72 and CD22 are responsible for setting the requirement of CD40 signaling for survival and proliferation of antigen-stimulated spleen B cells. PMID:12902484
results strongly suggest that the apoptosis preventing signal evoked by CD72 ligation is delivered through the pathway of NF-kappaB, c-Myc, p27(Kip1) and cyclin PMID:14734859
Strength of B-cell antigen receptor signals is strictly tuned by the interaction of CD100 with CD72; this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response. PMID:16113236
CD72 plays a dominant role as a negative regulator of BCR signaling in primary mature B lymphocytes. PMID:16621999
CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance PMID:18821699
CD72 is an inhibitory receptor on NK cells regulating cytokine production. PMID:19197938
CD72 activates extracellular signal-regulated kinase and c-Jun N-terminal kinase (but not p38 mitogen-activated protein kinase), synergizing with B cell receptor signals to induce proliferation of B cells in X-linked immunodeficiency. PMID:11466342