Recombinant Human Vasoactive intestinal polypeptide receptor 2 (VIPR2)

1. a novel gene duplication syndrome (10q21.2q21.3 microduplication) and new evidence for VIPR2 duplication, as a candidate gene for autism, are reported. PMID:27796743
2. Data suggest that VIPR2, which is a negative regulator of smooth muscle cell proliferation, might be a novel tumor suppressor gene in uterine leiomyosarcomas. PMID:29063609
3. The 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male Han Chinese patients. PMID:27156032
4. Lower CpG methylation of VIPR2 in the saliva of children with ADHD. PMID:26304033
5. CD4+ T cells in HIV infection show increased levels of expression of VPAC2 PMID:24469917
6. This study suggest that carriers of microduplication genotypes of VIPR2 are predisposed to SCZ in Han Chinese. PMID:24794882
7. Monocytes from Sjogren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis. PMID:24827637
8. Data indicate that VIP and PACAP increased macrophage resistance to HIV-1 replication by inducing the synthesis of beta-chemokines CCL3 and CCL5 and IL-10 following preferential activation of the receptors VPAC2 and PAC1. PMID:23818986
9. This is the first study to suggest a role of VIPR2 in the genetic susceptibility to high myopia. EGR1, JUN, FOS and VIP are unlikely to be important in predisposing humans to high myopia. PMID:23637909
10. Genetic testing for VIPR2-LCR-associated inversions should be performed on available cohorts of psychiatric patients to evaluate their potential pathogenic role PMID:23073313
11. Conclude that VPAC2/PAC1 receptors require NO in series to effect cutaneous active vasodilation during heat stress in humans. PMID:22961270
12. PACAP causes PAC1/VPAC2 receptor mediated hypertension and sympathoexcitation in normal and hypertensive rats. PMID:22886412
13. gene expression level and cAMP signaling of VIPR2 were increased in patients carrying 7q36.3 microduplications, thus implicating VIPR2 in the etiology of schizophrenia.[review] PMID:21721910
14. VPAC(2) receptor presents an extranuclear localization and its protein expression is lower than that of VPAC(1) receptor in human breast tissue samples PMID:20691743
15. VPAC2 and/or PAC1 receptor activation is involved in cutaneous active vasodilation in humans. PMID:20395540
16. Detection of beta-galactosidase marker for human VPAC2/VIPR2 in cells withinin the suprachiasmatic nucleus (SCN) of transgenic mice indicates that VPAC2 may contribute to autoregulation and/or coupling within the SCN core and to control of the SCN shell. PMID:15090046
17. analysis of a mutant form of VPAC2 shows its role in signaling and ligand binding PMID:15302876
18. a novel recombinant agonist for VPAC2 is not active against PAC1 PMID:16500728
19. The abnormal expression of VPCAP2-R mRNA in gallbladder tissue may play a role in the formation of gallbladder stones and gallbladder polyps PMID:16552823
20. VPAC2-R mRNA was visualized only in the cerebellum of 7-22-year-old subjects. PMID:16572459
21. splice variants may modify the immunoregulatory contributions of the VIP-VPAC2 axis PMID:16888203
22. identification and characterization of novel five-transmembrane(5TM) isoforms of VPAC2 PMID:16934434
23. altered expression of VPAC2 in activated CD4+ T cells derived from multiple sclerosis (MS) patients rendered CD4+ T cells less responsive to VIP and skewed the system to a predominantly T(h)1 direction. PMID:17077178
24. Daily stimulation of VPAC2, but not VPAC1 or PAC1, resulted in up to 90% inhibition of X4 or R5 productive infections in either cell lines or PBMCs. PMID:17257640
25. a novel mechanism of calmodulin in regulating PACAP signaling by possible interaction with the inactive state of PAC1 and VPAC2 receptors. PMID:19269029

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HGNC: 12695

UNIGENE: Hs.585052

KEGG: hsa:7434

STRING: 9606.ENSP00000262178

OMIM: 601970