Recombinant Human Sphingosine 1-phosphate receptor 4 (S1PR4)

1. High S1PR4 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis. PMID:28206609
2. S1PR4 missense mutation is associated with variant blood cell traits. PMID:27399967
3. Shear stress did not induce rapid dephosphorylation of beta-arrestin-1 or rapid internalization of S1P3, indicating no GPCR activation. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs. PMID:28148497
4. Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7/9 ligands to allow high IFN-alpha production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha secretion. PMID:26783340
5. S1P2 translocation to the nucleus is regulated by an autocrine loop involving S1P and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src to the nucleus appears to be regulated by a mechanism that does not involve S1P3 or S1P4. PMID:24486401
6. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists PMID:22119461
7. findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression. PMID:22460268
8. Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells. PMID:20837468
9. Data report that sphingosine 1-phosphate receptor 4 (S1P(4)) is specifically up-regulated during the development of human megakaryocytes from progenitor cells PMID:20686109
10. Mutation of the ligand selectivity residue from glutamic acid to glutamine confers lysophosphatidic acid sensitivity with preference for short-chain species PMID:15298705
11. FOXO1 controls the expression of L-selectin and EDG1 and EDG6, receptors that regulate lymphocyte trafficking PMID:18713968

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HGNC: 3170

UNIGENE: Hs.662006

KEGG: hsa:8698

STRING: 9606.ENSP00000246115

OMIM: 603751