S1PR4 Antibody

Code: CSB-PA136242

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

O95977

Target Names

S1PR4

Alternative Names

S1PR4; EDG6; Sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P4; Endothelial differentiation G-protein coupled receptor 6; Sphingosine 1-phosphate receptor Edg-6; S1P receptor Edg-6

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human S1PR4

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA136242(S1PR4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Rat kidney tissue, Primary antibody: CSB-PA136242(S1PR4 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds

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Target Background

Function(From Uniprot)

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

Gene References into Functions

High S1PR4 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis. PMID:28206609
S1PR4 missense mutation is associated with variant blood cell traits. PMID:27399967
Shear stress did not induce rapid dephosphorylation of beta-arrestin-1 or rapid internalization of S1P3, indicating no GPCR activation. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs. PMID:28148497
Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7/9 ligands to allow high IFN-alpha production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha secretion. PMID:26783340
S1P2 translocation to the nucleus is regulated by an autocrine loop involving S1P and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src to the nucleus appears to be regulated by a mechanism that does not involve S1P3 or S1P4. PMID:24486401
analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists PMID:22119461
findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression. PMID:22460268
Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells. PMID:20837468
Data report that sphingosine 1-phosphate receptor 4 (S1P(4)) is specifically up-regulated during the development of human megakaryocytes from progenitor cells PMID:20686109
Mutation of the ligand selectivity residue from glutamic acid to glutamine confers lysophosphatidic acid sensitivity with preference for short-chain species PMID:15298705
FOXO1 controls the expression of L-selectin and EDG1 and EDG6, receptors that regulate lymphocyte trafficking PMID:18713968

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Tissue Specificity

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone

Database Links

HGNC: 3170

UNIGENE: Hs.662006

KEGG: hsa:8698

STRING: 9606.ENSP00000246115

OMIM: 603751

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