Recombinant Human Presenilins-associated rhomboid-like protein, mitochondrial (PARL)-VLPs

1. PARL preserves mitochondrial membrane homeostasis via STARD7 processing and is emerging as a critical regulator of protein localization between mitochondria and the cytosol PMID:29301859
2. Study confirmed that common variants in PARL and PINK1 were associated with leprosy. Furthermore, PARL and PINK1 could physically interact with each other and were involved in the highly connected network formed by reported leprosy susceptibility genes. PMID:27876828
3. PDK2/PARL senses defects in mitochondrial bioenergetics. PMID:28178523
4. Adipogenic process can be dissected into 3 stages according to the participation of PARL-PINK1-Parkin system. Findings reveal the sequential adipogenic events directed by PARL-PINK1-Parkin system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease PMID:28641777
5. These findings enrich the allelic spectrum of ABCC5 in PACG. We identified no tagging SNP responsible for the association of the whole region. PMID:28813580
6. These results reveal a pro-apoptotic function of PARL and identify PARL-mediated Smac processing and cytochrome c release facilitated by OPA1-dependent cristae remodelling as two independent pro-apoptotic pathways in mitochondria. PMID:28288130
7. Its mutations are a rare cause of PD and genetic variants are neither strong nor common risk factors in Parkinson disease. PMID:26778534
8. pathogenic PINK1 mutants which are not cleaved by PARL affect PINK1 kinase activity and the ability to induce PARK2-mediated mitophagy. PMID:26101826
9. Common genetic variants of the PINK1 and PARL genes are unlikely to be involved in schizophrenia. PMID:25354644
10. the frequency of the haplotype AAC, and AAT were significantly higher in the unaffected cases and the frequencies of haplotype GGT were significantly higher in LHON cases PMID:23973714
11. Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. PMID:22915595
12. p.S77N variant, and, possibly, mutations in the PARL protein overall, are not a frequent cause of autosomal recessive early-onset Parkinson's disease PMID:21953724
13. work provides unexpected insights into the structural determinants regulating Parl stability and activity in vivo, and reveals a complex cascade of proteolytic events controlling the function of the protease in the mitochondrion PMID:21415861
14. PARL deficiency impairs PARKIN recruitment to mitochondria. PMID:21355049
15. the PARL-catalyzed removal of the Pink1 signal sequence in the canonical import pathway acts as a cellular checkpoint for mitochondrial integrity PMID:21426348
16. Mitochondrial protease PARL cleaves PINK1 at position A103. PMID:21138942
17. Data show that no association between PARL gene SNPs and LHON in Chinese patients with m.11778G>A. PMID:20711738
18. variants of PARL are suggested to influence cell death by apoptosis which has long been believed to intrigue the neurodegeneration of LHON. PMID:20407791
19. Results suggest that genetic variation within PARL influences mitochondrial abundance and integrity. PMID:19862556
20. results indicate a different function and mechanism of Hax1 in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 processing. PMID:19680265
21. PARL might mediate a developmentally regulated mitochondria-to-nuclei signaling through regulated proteolysis of its N terminus and release of the Pbeta peptide PMID:14732705
22. Variation in PSARL sequence and/or expression may be an important new risk factor for type 2 diabetes and other components of the metabolic syndrome. PMID:15729572
23. The Leu262Val variant is unlikely to be an important contributor to insulin resistance. PMID:17019603
24. the PARL rs3732581 genetic variant may have a role in insulin levels, metabolic syndrome and coronary artery disease PMID:18758826
25. Genetic variation of PARL may indicate earlier onset of type 2 diabetes and increased susceptibility to nephropathy and cardiovascular complications. PMID:19185381

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HGNC: 18253

UNIGENE: Hs.478469

KEGG: hsa:55486

STRING: 9606.ENSP00000325421

OMIM: 607858