Recombinant Human P2Y purinoceptor 8 (P2RY8)-VLPs

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Code: CSB-MP773043HU

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Size:

20ug100ug1mg

US$620

Quantity:

Express system: Mammalian cell

Species: Homo sapiens (Human)

Tag Info: C-terminal 10xHis-tagged

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Target Background

Product Details

Abbreviation

Recombinant Human P2RY8 protein-VLPs

Purity

Greater than 90% as determined by SEC-HPLC.

Target Names

P2RY8

Uniprot NO.

Q86VZ1

Research Area

Others

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

1-359aa

Target Protein Sequence

MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

42.0 kDa

Protein Length

Full Length

Tag Info

C-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80°C. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.

Troubleshooting and FAQs

Protein FAQs

Datasheet & COA

Please contact us to get it.

Images

CSB-MP773043HU is detected by Mouse anti-6*His monoclonal antibody
The purity of VLPs was greater than 90% as determined by SEC-HPLC

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Target Background

Function(From Uniprot)

Probable receptor for purines coupled to G-proteins.

Gene References into Functions

P2RY8-CRLF2 fusion is associated with childhood B-cell acute lymphoblastic leukemia. PMID:27637012
P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner. PMID:26573295
P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone. PMID:23091296
Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia. PMID:22484421
Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 rearrangement. PMID:20378752
P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia PMID:17487742
SOX5 is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma PMID:17554380