P2RY8 Antibody

CSB-PA003634

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Size:

50μg100μg

US$119

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Species Reactivity: Human

Raised in: Rabbit

Application: WB, IF, ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

Q86VZ1

Target Names

P2RY8

Alternative Names

P2RY8; P2Y purinoceptor 8; P2Y8

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the Internal region of Human P2RY8.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, IF, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol ELISA Protocol

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of HuvEc cells using P2RY8 Polyclonal Antibody

Description

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Target Background

Function

Probable receptor for purines coupled to G-proteins.

Gene References into Functions

P2RY8-CRLF2 fusion is associated with childhood B-cell acute lymphoblastic leukemia. PMID:27637012
P2RY8 promotes clustering of activated B cells within follicles in a follicular dendritic cell (FDC)-dependent manner. PMID:26573295
P2RY8-CRLF2-positive clones do not have the necessary proliferative or selective advantage to evolve into a disease-relevant relapse clone. PMID:23091296
Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia. PMID:22484421
Study reports an extremely high incidence of relapse (71% +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic leukemia patients with P2RY8-CRLF2 rearrangement. PMID:20378752
P2RY8 is expressed in leukemic cells and has an unexpected role in the pathogenesis of acute leukemia PMID:17487742
SOX5 is upregulated by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma PMID:17554380