Recombinant Human N-formyl peptide receptor 3 (FPR3)

1. The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis. PMID:23746112
2. transcriptional variations of FPR3 occur by an alternative promoter during primate evolution. PMID:21717223
3. F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and able to induce recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils PMID:21709160
4. Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins. PMID:20972812
5. Human dendritic cells express functional FPRL2 throughout maturation. FPRL2 & its endogenous ligand may be involved in regulating DC trafficking during Ag uptake & processing s well as the T-cell-stimulating phase of the immune responses. PMID:12223529
6. Activation of FPRL2 inhibits lipopolysaccharide-induced dendritic cell maturation. PMID:16002663
7. However, F2L inhibits formyl peptide receptor (FPR) and FPRL1 activities, resulting in the inhibition of intracellular calcium increases, and superoxide generation induced by N-formyl-Met-Leu-Phe, MMK-1, or Trp-Lys-Tyr-Met-Val-d-Met in neutrophils. PMID:17577578
8. FPRL2 is expressed and functional in macrophages differentiated from monocytes in vitro in different conditions PMID:19342677
9. Human monocytes express FPR1, FPR2, and FPR3; human neutrophils express FPR1 and FPR2, but not FPR3. PMID:19843937

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HGNC: 3828

UNIGENE: Hs.445466

KEGG: hsa:2359

STRING: 9606.ENSP00000341821

OMIM: 136539