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Recombinant Human Mas-related G-protein coupled receptor member X3

Recombinant Human Mas-related G-protein coupled receptor member X3

Code: CSB-CF850382HU

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Express system: in vitro E.coli expression system

Species: Homo sapiens (Human)

Tag Info: MRGPRX3

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Product Details
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Target Background

Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

MRGPRX3

Uniprot NO.

Q96LB0

Alternative Names

G protein coupled receptor SNSR1; G protein coupled receptor SNSR2; G protein-coupled receptor MRGX 3; G protein-coupled receptor MRGX3 ; GPCR; Mas related GPCR member X3; Mas-related G protein coupled MRGX 3; Mas-related G protein coupled MRGX3; Mas-related G-protein coupled receptor member X3; MAS-related GPR, member X3; MRGPRX3; MRGX3; MRGX3_HUMAN; Sensory neuron-specific G-protein coupled receptor 1; Sensory neuron-specific G-protein coupled receptor 1/2; SNSR1; SNSR2

Species

Homo sapiens (Human)

Source

in vitro E.coli expression system

Mol. Weight

Sensory neuron-specific G-protein coupled receptor 1/2

Protein Length

Full Length

Tag Info

MRGPRX3
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Han S.-K.
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Simon M.I.

Reconstitution

694648

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

in vitro E.coli expression system

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Target Background

Function(From Uniprot)

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins.

Gene References into Functions

Our data demonstrate that GPR182 is an endothelial subtype-specific marker for human sinusoidal EC of the liver, spleen, lymph node and bone marrow. In addition, we provide evidence for GPR182-dependent downstream signaling via ERK and SRF pathways that may be involved in regulating endothelial subtype-specific sinusoidal differentiation and sinusoidal functions such as permeability. PMID:29408502
Potential of GPCRs to modulate MAPK and mTOR pathways in different stages of the neurodegenerative disease. PMID:28189739
overexpression of the human MrgX3 gene causes a disturbance of the normal cell-differentiation process PMID:15809047

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family, Mas subfamily

Tissue Specificity

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Database Links

HGNC: 17980

UNIGENE: Hs.380177

KEGG: hsa:117195

STRING: 9606.ENSP00000379571