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Recombinant Human Mas-related G-protein coupled receptor member X3

Recombinant Human Mas-related G-protein coupled receptor member X3

Code: CSB-CF850382HU

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Express system: in vitro E.coli expression system

Species: Homo sapiens (Human)

Tag Info: MRGPRX3

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Target Background

Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

MRGPRX3

Uniprot NO.

Q96LB0

Species

Homo sapiens (Human)

Source

in vitro E.coli expression system

Mol. Weight

Sensory neuron-specific G-protein coupled receptor 1/2

Protein Length

Full Length

Tag Info

MRGPRX3
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Simon M.I.

Reconstitution

694648

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Target Background

Function(From Uniprot)

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins.

Gene References into Functions

Our data demonstrate that GPR182 is an endothelial subtype-specific marker for human sinusoidal EC of the liver, spleen, lymph node and bone marrow. In addition, we provide evidence for GPR182-dependent downstream signaling via ERK and SRF pathways that may be involved in regulating endothelial subtype-specific sinusoidal differentiation and sinusoidal functions such as permeability. PMID:29408502
Potential of GPCRs to modulate MAPK and mTOR pathways in different stages of the neurodegenerative disease. PMID:28189739
overexpression of the human MrgX3 gene causes a disturbance of the normal cell-differentiation process PMID:15809047

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family, Mas subfamily

Tissue Specificity

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Database Links

HGNC: 17980

UNIGENE: Hs.380177

KEGG: hsa:117195

STRING: 9606.ENSP00000379571