Recombinant Human Integrin beta-6 (ITGB6)

1. these findings demonstrate that JunB and CBP-mediated histone hyperacetylation are responsible for TGF-beta1 induced ITGB6 transcription in oral squamous cell carcinoma (OSCC) cells, suggesting that epigenetic mechanisms are responsible for the active transcription expression of ITGB6 induced by TGF-beta1 in OSCC cells. PMID:29274289
2. Taken together, our results indicate that integrin beta6 promotes tumor invasiveness in a Rac1-dependent manner and is a potential biomarker for tumor metastasis. PMID:27440504
3. The increased regional and distant metastasis observed in HER2+ tumors with high levels of ITGB6 might be mediated by the canonical Rho-Rac pathway through increased expression of MMP9 and MMP15. PMID:27184932
4. Rare missense variant c.898G>A (p.(Glu300Lys)) in ITGB6 causes not only dentogingival anomalies but also intellectual disability and alopecia. PMID:26695873
5. Treatment of these cells with the dual-specificity tyrosine-kinase inhibitor lapatinib led to downregulation of epithelial-to-mesenchymal transition as indicated by lower levels of SNAI1 and SNAI2 transcripts, integrin AVB6, and matrix metalloproteinase 9 protein PMID:28349782
6. Integrin b6 markedly promoted the proliferation and invasion of pancreatic carcinoma cells and induced ETS1 phosphorylation in an ERK-dependent manner, leading to the upregulation of matrix metalloprotease-9, which is essential for b6-mediated invasiveness of pancreatic carcinoma cells PMID:26547582
7. AG/GG genotypes of ITGB6 rs4665162 gene were associated with a higher risk of radiation pneumonitis (RP) in patients with lung cancer receiving radiotherapy and thus may serve as a reliable predictor of RP. PMID:26449830
8. A novel homozygous ITGB6 mutation causing isolated amelogenesis imperfecta, and this advances the understanding of normal and pathologic enamel development. PMID:25431241
9. These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease. PMID:26861876
10. Integrin beta6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas PMID:24844802
11. The results indicated that MMP-9-degraded Fibronectin can adjust constituents of the avb6 heterodimers at the early phase and significantly elevate amounts of b6 integrin subunits at a later period PMID:26134759
12. Results shows that ITGB6 promoter contains a functional TATA box and that STAT3 and C/EBPalpha are involved in its positive regulation in oral squamous cell carcinoma cells. PMID:25816241
13. targeting eIF4E in integrin ava6 expressing tumors can be a potential therapeutic strategy for patients with colon cancer. PMID:25982998
14. In conclusion NSCLC cell lines, positive for E-Cadherin,EpCAM and avb6 expression, activate normal fibroblasts through avbeta6/TGFbeta signalling in vitro, and influence both gene expression and response to therapeutic agents. PMID:24488011
15. The deficiency of avb6-related hyperpermeability in T84 monolayers could be compensated by adding exogenous avb6 to the culture. PMID:24677750
16. Expression of the alphavbeta6 integrin subunit seems to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases. PMID:25150423
17. ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta. PMID:24305999
18. Brain metastases ITGB6 expression exhibits considerable heterogeneity according to tumor origin. PMID:24294359
19. ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with alphavbeta6 integrin PMID:24055471
20. Data indicate that integrin beta6, CD46, tissue factor, and chromosome 14 open reading frame 1 (C14ORF1), were identified as overexpressed on pancreatic cancer cell lines. PMID:21934552
21. These data identify a novel interaction between Psor and beta6 and demonstrate that it is required for alphavbeta6-dependent invasion by carcinoma cells. PMID:21132011
22. Integrin beta6 plays a role in the compromised wound healing associated with the diabetic state. PMID:20854469
23. Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8. PMID:19920174
24. Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit PMID:11992542
25. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema PMID:12634787
26. upon ligation of integrin beta6 with fibronectin, beta6 complexed with Fyn and activated it, activating a pathway leading to activation of the matrix metalloproteinase-3 gene, and promoting oral SCC cell proliferation and experimental metastasis in vivo PMID:12917446
27. beta(6) integrin is not normally expressed in adult native or transplanted kidneys but is commonly up-regulated in the distal tubule in disease. PMID:15458435
28. Constitutively activated STAT3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through ITGB6. PMID:17438134

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HGNC: 6161

UNIGENE: Hs.470399

KEGG: hsa:3694

STRING: 9606.ENSP00000283249

OMIM: 147558