Recombinant Human Galactoside 3 (4)-L-fucosyltransferase (FUT3)

1. High FUT3 expression is associated with breast cancer. PMID:26908442
2. the high expressions of BCL6 and Lewis y antigen are associated with development, high tumor burden, and worse prognosis of ovarian cancer and targeting BCL6 could be a novel therapeutic strategy for ovarian cancer treatment. PMID:28671040
3. the miRNA expression vector which targets the FUT3 gene can effectively inhibit the proliferation, migration and invasion abilities of KATO-III cells. PMID:27453266
4. Polymorphisms in FUT3 and its intestinal expression might be associated with ulcerative colitis pathogenesis. PMID:26766790
5. Data suggest that fucosyltransferase 3 (FUT3) gene rs28362459 and rs3745635 single nucleotide polymorphisms (SNPs) may engender the increased risk of ileocolonic and ileal Crohn's disease (CD). PMID:26663064
6. that the absence of alpha1,3/4-fucosyltransferase enzyme is related to breast's invasive breast carcinoma PMID:26321244
7. Mutations of FUT3 (rs28362459) and (rs3745635) might influence the lesion locations in CD patients. PMID:24720527
8. Obtained FST values reveal distinct frequencies of the FUT3 SNPs between the present sample and its representative ancestral populations. PMID:23922852
9. down-regulation of FUT3 and FUT5 reduces the expression of sialyl-Lewis antigens and the adhesion capacities of gastric cancer cells and allows to identify the specific alpha1-3,4 fucosyltransferases implicated in the Lewis antigens synthesis PMID:21978830
10. Elevated expression of Topo-I and Topo-II beta is found in Lewis(y) antigen-overexpressing ovarian cancer cells. PMID:21542140
11. LeY is carried by integrin alphavbeta3 and plays a critical role in attachment to cultured cells. LeY activates integrin alphavbeta3/focal adhesion kinase (FAK) signaling. PMID:20605574
12. At physiological levels of wall shear stress, the number of flowing cancer cells recruited to the microtube surface was dramatically reduced by FUT3 knockdown PMID:20833389
13. Lewis-negative genotype was associated with invasive ductal breast carcinoma but not with anatomoclinical parameters PMID:20514537
14. GALNT14 and FUT3/6 H-scores were significantly higher in non-small cell lung cancer cell lines sensitive to dulanermin and drozitumab versus resistant cell lines PMID:20179215
15. Increased expression of Lewis y antigen plays an important role in promoting cell proliferation through activating PI3K/Akt signaling pathway in ovarian carcinoma-derived RMG-I cells. PMID:20003467
16. PCR using sequence-specific primers DNA enables efficient genotyping of clinical samples PMID:11668626
17. Sialy Lewis-X antigens play an important role liver metastases of colon carcinoma. PMID:11819805
18. Distribution of Lewis (FUT3)genotype and allele frequencies by ethnicity in a United States population. PMID:12424536
19. Cys, Gln, and Tyr residues are important for FT3wt sorting into the transport vesicles possibly due to interactions with other membrane proteins PMID:12493760
20. study of the Lewis gene polymorphisms in a Caucasian Portuguese population with a high rate of H. pylori infection, and evaluation of the implications of mutant enzymes in Le(b) expression in the gastric mucosa PMID:12730721
21. results indicated that Mn2+ bound the enzyme and increased its affinity for the acceptor PMID:14977360
22. The heterologous enzyme hFUT3 was strongly expressed and fully functional in transgenic tobacco, which showed a delay in growth linked to a reduction of internode length. PMID:15331092
23. cloning and characterization of the promoter; strong correlation between the promoter activity and high expression of sialyl Le(a) observed in colon carcinoma cell lines seem to confirm the important regulatory role of FUT3 in synthesis of sialyl Le(a) PMID:16199102
24. LeX motif present in human milk can bind to dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), thereby preventing the capture and subsequent transfer of HIV-1 to CD4+ T lymphocytes. PMID:16239964
25. T3 overexpression in gastric cells depends upon promoter hypomethylation and FUT3 is responsible for overexpression of Le(a) in gastric cells, in vitro PMID:16427187
26. functional mutations of the FUT3 gene may be associated with an increased atherothrombotic disease prevalence, especially among abstainers PMID:17383304
27. increased CD15 expression is not due to de novo biosynthesis of CD15, but results predominantly from induction of alpha(2-3)-sialidase activity PMID:18953356
28. Expression of sLex antigen in breast cancer is not associated with breast cancer survival. PMID:18977761
29. These findings indicate that Lewis y antigen have the ability to enhance the proliferation and elevate the survival rates of RMG-I cells, which can promote the genesis and development of ovarian carcinoma PMID:19137814
30. Sequence analysis of FUT3 identified many SNPs, but most of them are in complete linkage disequilibrium with previously reported SNPs responsible for the Lewis-negative phenotype. PMID:19175549
31. results suggested that PKR is the primary target for HSV-1 early RNA during induction of FUT3, FUT5, and FUT6 PMID:19349624
32. in breast cancer there was a limited humoral immune response through Lewis y/IgM/CIC levels detection which correlated with MUC1/IgM/CIC PMID:19715603

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HGNC: 4014

UNIGENE: Hs.169238

KEGG: hsa:2525

STRING: 9606.ENSP00000305603

OMIM: 111100