Abbreviation
Recombinant Human CXCR2 protein-VLPs (Active)
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CXCR2 at 2 μg/mL can bind Anti-CXCR2 recombinant antibody (CSB-RA011673MA1HU). The EC50 is 0.3741-0.4671 ng/mL. The VLPs (CSB-MP3838) is negative control.
Alternative Names
C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD antigen CD182
Species
Homo sapiens (Human)
Expression Region
1-360aa
Target Protein Sequence
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Full Length
Tag Info
C-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Buffer
Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4
Storage
Store at -20°C/-81°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Lead Time
3-7 business days
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
Shelf Life
The shelf life is related to many factors, storage state, storage temperature and the stability of the product itself. Generally, the shelf life of lyophilized form is 6 months at -20°C/-80°C from the date of receipt.
Datasheet & COA
Please contact us to get it.
Images
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CSB-MP011673HU(A4) is detected by Mouse anti-6*His monoclonal antibody.
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Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CXCR2 at 2 μg/ml can bind Anti-CXCR2 recombinant antibody (CSB-RA011673MA1HU). The EC50 is 0.3741-0.4671 ng/mL.
The VLPs (CSB-MP3838) is negative control.
Description
CXCR2 mediates neutrophil recruitment and tumor-associated inflammation, making it a target of interest in cancer immunology and metastasis research. This full-length receptor (aa 1–360) is presented in virus-like particles produced in mammalian cells, a format that preserves native membrane topology and post-translational modifications critical for conformational epitope display. Functional ELISA demonstrates specific antibody binding with an EC50 of 0.37–0.47 ng/mL, confirming that the receptor retains its native structure and supports use in therapeutic antibody epitope mapping, competitive inhibition screening, and blocking antibody validation assays. With endotoxin levels below 1.0 EU/μg, this VLP-displayed CXCR2 meets the quality thresholds commonly required for ligand-binding studies, SPR or BLI affinity characterization, and small-molecule inhibitor screening campaigns targeting chemokine receptor signaling in oncology.
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