TAB1 Recombinant Monoclonal Antibody

Code: CSB-RA243394A0HU

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Size:

50μl100μl

US$210

Quantity:

Species Reactivity: Human

Application: ELISA, IHC, FC

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Target Background

Product Details

Uniprot NO.

Q15750

Target Names

TAB1

Alternative Names

2310012M03Rik antibody; 3'-Tab1 antibody; MAP3K7IP 1 antibody; MAP3K7IP1 antibody; MGC57664 antibody; Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody; TAB 1 antibody; TAB1 antibody; TAB1_HUMAN antibody; TAK1 binding protein 1 antibody; TAK1-binding protein 1 antibody; TGF beta activated kinase 1 binding protein 1 antibody; TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody; TGF-beta-activated kinase 1-binding protein 1 antibody; Transforming growth factor beta activated kinase binding protein 1 antibody

Species Reactivity

Human

Immunogen

A synthesized peptide derived from human TAB1

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone No.

11B7

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Scope Application

ELISA Protocol Immunohistochemistry (IHC) Protocol Flow Cytometry (FC) Protocol

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:200
FC	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

IHC image of CSB-RA243394A0HU diluted at 1:100 and staining in paraffin-embedded human stomach tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Overlay Peak curve showing jurkat cells stained with CSB-RA243394A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

Description

TAB1 (TGF-beta-activated kinase 1-binding protein 1) serves as a critical regulatory component in inflammatory and stress response signaling pathways. As an essential activator of TAK1 (MAP3K7), TAB1 plays a pivotal role in mediating signals downstream of TGF-beta, IL-1, and Toll-like receptors, making it a key focus for researchers investigating innate immunity, inflammatory diseases, and cellular stress responses.

This recombinant monoclonal antibody, clone 11B7, offers the reproducibility and consistency that demanding experimental workflows require. Developed using recombinant technology with a sequence-defined approach, this antibody eliminates the lot-to-lot variability that can compromise longitudinal studies or multi-site collaborations. The rabbit host origin combined with monoclonal specificity ensures reliable detection of human TAB1 across your experimental timeline.

Validation studies demonstrate robust performance in multiple applications, providing flexibility for diverse research needs. Immunohistochemistry testing in paraffin-embedded human stomach tissue using a Leica Bond system with citrate buffer antigen retrieval shows clear specific staining at 1:100 dilution, confirming suitability for tissue-based studies. Flow cytometry analysis in Jurkat cells reveals a distinct positive shift compared to isotype control, with fixed and permeabilized cells showing reliable intracellular detection at 1:100 dilution. These validated applications, along with ELISA compatibility, support comprehensive protein expression analysis from tissue architecture to single-cell resolution.

Supplied in a glycerol-containing buffer optimized for long-term stability, this antibody is well-suited for research programs exploring NF-κB signaling, inflammatory pathway regulation, and TAK1-mediated kinase cascades in human samples.

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Target Background

Function(From Uniprot)

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Gene References into Functions

High TAB1 expression is associated with colorectal cancer. PMID:29328486
TAB1 was identified as a functional target of miR-134, and the expression of TAB1 was increased by the transcription factors of NF-kappaB1, c-Rel, and ELK1 via miR-134. PMID:28206956
we show that IL-1 induces robust p38a activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 through a positive feedback loop. PMID:27314954
TAK1/TAB1 expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis. PMID:26884850
miR-29a repressed TAB1-mediated TIMP-1 production in dermal fibroblasts, demonstrating that miR-29a may be a therapeutic target in SSc. PMID:25549087
Data indicate that mitogen-activated protein kinase (MAPK) p38 activation is triggered by AMP-activated protein kinases (AMPK) and mediated by TAB1 protein. PMID:25151490
The amino acid sequence between positions 373 and 502 of TAB1 is required for TP interaction. PMID:24462677
USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. PMID:23825189
We found that endothelial TAK1 and TAB2, but not TAB1, were critically involved in vascular formation PMID:22972987
TAK1 plays a critical role in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. PMID:22525462
data suggest a complex role of aa 452-457 of TAB1 in controlling p38 MAPK activity and subcellular localization and implicate these residues in TAK1- or p38 MAPK-dependent post-transcriptional control of gene expression PMID:22216226
Phosphorylation and polyubiquitination of TAK1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus vGPCR. PMID:21159881
Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID:20805296
Co-expression of TAK1 and TAB1 resulted in a functional and active TAK1-TAB1 complex capable of directly activating full-length heterotrimeric mammalian AMP-activated protein kinase (AMPK) in vitro. PMID:20538596
interaction with p38alpha leads to autophosphorylation and activation of p38alpha PMID:11847341
The TAK1-TAB1 fusion protein is a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways PMID:12372426
TauAlphaBeta1beta is involved in regulating p38alpha activity in physiological conditions PMID:12429732
These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. PMID:12482967
characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop; TAB1 and TAB2 were differentially involved in the phosphorylation of TAK1 PMID:15590691
Determinants that control the specific interactions between TAB1 and MAPK14 are identified. PMID:16648477
The protein phosphatase 2C alpha fold is conserved in TAB1(a TAK1 regulatory subunit) but some AAs needed for dual metal-binding & catalysis are missing. It is a pseudophosphatase, & may bind/regulate access to phosphorylated AAs on downstream substrates. PMID:16879102
a TAB1:TAK1:IKK beta:NF-kappaB signaling axis forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta PMID:18316610
TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK1-TAB1, which activates IKK signaling to NF-kappaB. PMID:18456659
periostin is involved in the suppression of cell invasiveness via the TAB1/TAK1 signaling pathway. PMID:19578758