Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1)

1. High TAB1 expression is associated with colorectal cancer. PMID:29328486
2. TAB1 was identified as a functional target of miR-134, and the expression of TAB1 was increased by the transcription factors of NF-kappaB1, c-Rel, and ELK1 via miR-134. PMID:28206956
3. we show that IL-1 induces robust p38a activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 through a positive feedback loop. PMID:27314954
4. TAK1/TAB1 expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis. PMID:26884850
5. miR-29a repressed TAB1-mediated TIMP-1 production in dermal fibroblasts, demonstrating that miR-29a may be a therapeutic target in SSc. PMID:25549087
6. Data indicate that mitogen-activated protein kinase (MAPK) p38 activation is triggered by AMP-activated protein kinases (AMPK) and mediated by TAB1 protein. PMID:25151490
7. The amino acid sequence between positions 373 and 502 of TAB1 is required for TP interaction. PMID:24462677
8. USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. PMID:23825189
9. We found that endothelial TAK1 and TAB2, but not TAB1, were critically involved in vascular formation PMID:22972987
10. TAK1 plays a critical role in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. PMID:22525462
11. data suggest a complex role of aa 452-457 of TAB1 in controlling p38 MAPK activity and subcellular localization and implicate these residues in TAK1- or p38 MAPK-dependent post-transcriptional control of gene expression PMID:22216226
12. Phosphorylation and polyubiquitination of TAK1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus vGPCR. PMID:21159881
13. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID:20805296
14. Co-expression of TAK1 and TAB1 resulted in a functional and active TAK1-TAB1 complex capable of directly activating full-length heterotrimeric mammalian AMP-activated protein kinase (AMPK) in vitro. PMID:20538596
15. interaction with p38alpha leads to autophosphorylation and activation of p38alpha PMID:11847341
16. The TAK1-TAB1 fusion protein is a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways PMID:12372426
17. TauAlphaBeta1beta is involved in regulating p38alpha activity in physiological conditions PMID:12429732
18. These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. PMID:12482967
19. characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop; TAB1 and TAB2 were differentially involved in the phosphorylation of TAK1 PMID:15590691
20. Determinants that control the specific interactions between TAB1 and MAPK14 are identified. PMID:16648477
21. The protein phosphatase 2C alpha fold is conserved in TAB1(a TAK1 regulatory subunit) but some AAs needed for dual metal-binding & catalysis are missing. It is a pseudophosphatase, & may bind/regulate access to phosphorylated AAs on downstream substrates. PMID:16879102
22. a TAB1:TAK1:IKK beta:NF-kappaB signaling axis forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta PMID:18316610
23. TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK1-TAB1, which activates IKK signaling to NF-kappaB. PMID:18456659
24. periostin is involved in the suppression of cell invasiveness via the TAB1/TAK1 signaling pathway. PMID:19578758

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HGNC: 18157

UNIGENE: Hs.507681

KEGG: hsa:10454

STRING: 9606.ENSP00000216160

OMIM: 602615