CSF1 Recombinant Monoclonal Antibody

Code: CSB-RA006043MA1HU

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Size:

50μl100μl

US$210

Quantity:

Species Reactivity: Human

Application: ELISA

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Target Background

Product Details

Uniprot NO.

P09630

Target Names

CSF1

Alternative Names

CP25 antibody; HHO.C8 antibody; Homeo box 3C antibody; Homeo box C6 antibody; Homeo box C8 protein antibody; Homeobox C6 antibody; Homeobox protein CP25 antibody; Homeobox protein HHO.C8 antibody; Homeobox protein Hox-3C antibody; Homeobox protein Hox-C6 antibody; HOX3 antibody; HOX3C antibody; Hoxc6 antibody; HXC6_HUMAN antibody

Species Reactivity

Human

Immunogen

Recombinant Human CSF1 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

17F4

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA

Recommended Dilution

Application	Recommended Dilution
ELISA	1:5000-1:50000

Protocols

ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

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The Binding Activity of Human CSF1 with Anti-CSF1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein (CSB-MP006043HU1) at 2 μg/mL can bind Anti-CSF1 recombinant antibody. The EC₅₀ is 4.291-4.988 ng/mL.

Description

Colony-stimulating factor 1, also known as macrophage colony-stimulating factor, plays a central role in regulating the survival, proliferation, and differentiation of mononuclear phagocytes. This cytokine governs macrophage biology across diverse physiological and pathological contexts, from tissue homeostasis and immune responses to tumor microenvironment modulation. Understanding CSF1 signaling pathways has become increasingly important for researchers investigating inflammatory diseases, cancer immunology, and developmental biology.

This recombinant monoclonal antibody against human CSF1, clone 17F4, offers the consistency and reliability that demanding quantitative assays require. Produced using recombinant technology with a defined human IgG1 framework, this antibody provides sequence-level reproducibility between lots, eliminating the variability that can compromise longitudinal studies or assay development efforts. Researchers can confidently establish protocols knowing that performance characteristics will remain stable across future orders.

Functional validation demonstrates robust binding activity in ELISA applications, with the antibody recognizing immobilized human CSF1 protein at concentrations as low as 2 μg/mL. The determined EC50 range of 4.291 to 4.988 ng/mL reflects strong binding affinity suitable for sensitive detection applications. Recommended working dilutions span from 1:5000 to 1:50000, providing flexibility to optimize signal-to-noise ratios across different experimental setups and sample concentrations.

Supplied in a stabilized liquid format containing 50% glycerol in PBS with Proclin 300 preservative, this antibody is ready for immediate use without reconstitution. The affinity-purified preparation ensures minimal background interference. For researchers exploring epigenetics, nuclear signaling, or cytokine biology, this CSF1 antibody delivers the technical performance needed for reliable, reproducible results in immunoassay-based detection workflows.

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Target Background

Function(From Uniprot)

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene References into Functions

our findings indicate that HOXC6 plays an important role in the progress and prognosis of human glioma and promotes glioma U87 cell growth through the WIF-1/Wnt signaling pathway PMID:30228024
Overall, the data show that miR-185 could negatively target HOXC6 to suppress cell proliferation, promotes apoptosis and autophagy through inhibiting TGF-beta1/mTOR axis in nasopharyngeal carcinoma (NPC). Thus, miR-185 is useful strategy for the treatment of NPC. PMID:29991129
HOXC6 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID:27108162
HOXC6 thus appears to promote colorectal cancer cell proliferation and tumorigenesis through autophagy inhibition PMID:27081081
Increased expression of HOXC6 in gastric cancer cell lines significantly activated extracellular signalregulated kinase signaling and upregulated MMP9. The HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 promotes migration and invasion of gastric cancer cells. PMID:27573865
oxidized low-density lipoprotein (Ox-LDL) decreased expression of HOXC-AS1 and HOXC6 in a time-dependent manner PMID:27574949
HOXC6 has a role in all prostate cancer stages, particularly in prostate cancer cell proliferation. PMID:26310814
Data demonstrate significant downregulation of HOXC6 in serous ovarian cancer and low protein level is associated with high-grade tumors. PMID:26046583
Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo. PMID:25725483
HOXC6 can be used as a prognostic marker in esophageal squamous cell carcinoma PMID:24525058
HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1 PMID:22907429
Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations. PMID:23581417
HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression. PMID:22896703
These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha and ERbeta, transcriptionally regulate HOXC6 in an estrogen-dependent manner. PMID:21683083
proapoptotic repression targets include neutral endopeptidase (NEP) and insulin-like growth factor binding protein-3 (IGFBP-3) PMID:15637592
HOXC6 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells. PMID:17488478