HOXC6 Antibody

Code: CSB-PA016376

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Size:

100μl

US$297

Quantity:

Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,WB

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Target Background

Product Details

Uniprot NO.

P09630

Target Names

HOXC6

Alternative Names

CP25 antibody; HHO.C8 antibody; Homeo box 3C antibody; Homeo box C6 antibody; Homeo box C8 protein antibody; Homeobox C6 antibody; Homeobox protein CP25 antibody; Homeobox protein HHO.C8 antibody; Homeobox protein Hox-3C antibody; Homeobox protein Hox-C6 antibody; HOX3 antibody; HOX3C antibody; Hoxc6 antibody; HXC6_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from C-terminal of Human HOXC6.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot analysis of extracts from HUVEC cells, using HOXC6 antibody.

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Target Background

Function(From Uniprot)

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene References into Functions

our findings indicate that HOXC6 plays an important role in the progress and prognosis of human glioma and promotes glioma U87 cell growth through the WIF-1/Wnt signaling pathway PMID:30228024
Overall, the data show that miR-185 could negatively target HOXC6 to suppress cell proliferation, promotes apoptosis and autophagy through inhibiting TGF-beta1/mTOR axis in nasopharyngeal carcinoma (NPC). Thus, miR-185 is useful strategy for the treatment of NPC. PMID:29991129
HOXC6 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer. PMID:27108162
HOXC6 thus appears to promote colorectal cancer cell proliferation and tumorigenesis through autophagy inhibition PMID:27081081
Increased expression of HOXC6 in gastric cancer cell lines significantly activated extracellular signalregulated kinase signaling and upregulated MMP9. The HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 promotes migration and invasion of gastric cancer cells. PMID:27573865
oxidized low-density lipoprotein (Ox-LDL) decreased expression of HOXC-AS1 and HOXC6 in a time-dependent manner PMID:27574949
HOXC6 has a role in all prostate cancer stages, particularly in prostate cancer cell proliferation. PMID:26310814
Data demonstrate significant downregulation of HOXC6 in serous ovarian cancer and low protein level is associated with high-grade tumors. PMID:26046583
Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo. PMID:25725483
HOXC6 can be used as a prognostic marker in esophageal squamous cell carcinoma PMID:24525058
HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1 PMID:22907429
Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations. PMID:23581417
HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression. PMID:22896703
These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha and ERbeta, transcriptionally regulate HOXC6 in an estrogen-dependent manner. PMID:21683083
proapoptotic repression targets include neutral endopeptidase (NEP) and insulin-like growth factor binding protein-3 (IGFBP-3) PMID:15637592
HOXC6 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells. PMID:17488478