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Recombinant Mouse Ras-related protein R-Ras (Rras)

Recombinant Mouse Ras-related protein R-Ras (Rras)

Code: CSB-EP020513MO

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Size:

20ug100ug1mg

US$256

Quantity:

Express system: E.coli

Species: Mus musculus (Mouse)

Tag Info: C-terminal 6xHis-tagged

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Target Background

Product Details

Abbreviation

Recombinant Mouse Rras protein

Purity

≥85% as determined by SDS-PAGE.

Target Names

Rras

Uniprot NO.

P10833

Research Area

Others

Species

Mus musculus (Mouse)

Source

E.coli

Expression Region

1-215aa

Mol. Weight

30.4 kDa

Protein Length

Full Length of Mature Protein

Tag Info

C-terminal 6xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

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Datasheet & COA

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Target Background

Function(From Uniprot)

Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.

Gene References into Functions

Taken together, despite having reduced number of conventional DC's in the R-Ras KO mice and low expression of CD80 on DC's, the R-Ras KO mice are capable of mounting papain-induced IgE responses comparable to that of the WT mice. PMID:28497586
R-Ras is pro-tumourigenic in the mouse DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment. PMID:26133397
the data provide evidence for a role of R-Ras in the mediation of chemokine receptor-mediated signaling in migrating T cells in the high endothelial venules. PMID:26710069
Study reveals a novel role for the R-Ras GTPase in the brain by demonstrating its requirement for high-frequency stimulation long-term potentiation in the CA1 hippocampus in adult mice, as well as contextual discrimination PMID:25043327
a novel role for R-Ras in promoting autoimmunity through negative regulation of natural regulatory T cell numbers by inhibiting the development of MHCII(low) DC with tolerogenic potential. PMID:24771856
Geranylgeranylation was required for membrane anchorage of Rras, whereas palmitoylation was required for exit from the Golgi in post-Golgi vesicle membranes and trafficking to the plasma membrane. PMID:22751447
These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization. PMID:22897853
First demonstration of a role for R-Ras in cell-mediated immunity and further expand on the complexity of small G-protein signaling in dendritic cells. PMID:22174156
R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. PMID:21572048
R-Ras is a small GTPase of the Ras family that regulates cell survival and integrin activity and is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. [R-ras] PMID:16286923
Data suggest that R-Ras and TC-21 play a role in facilitating branching and growth in early ureteric bud development, whereas H-Ras might favor cell migration and elongation of tubules, events that occur later in development. PMID:16467383
Rnd2 bound to Plexin-D1 in cortical neurons, and Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical neurons required Rnd2 and down-regulation of R-Ras activity. PMID:19136556

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Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

Protein Families

Small GTPase superfamily, Ras family

Database Links

UNIGENE: Mm.389894

KEGG: mmu:20130

STRING: 10090.ENSMUSP00000042150

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