Recombinant Mouse Ras-related protein R-Ras (Rras)

1. Taken together, despite having reduced number of conventional DC's in the R-Ras KO mice and low expression of CD80 on DC's, the R-Ras KO mice are capable of mounting papain-induced IgE responses comparable to that of the WT mice. PMID:28497586
2. R-Ras is pro-tumourigenic in the mouse DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment. PMID:26133397
3. the data provide evidence for a role of R-Ras in the mediation of chemokine receptor-mediated signaling in migrating T cells in the high endothelial venules. PMID:26710069
4. Study reveals a novel role for the R-Ras GTPase in the brain by demonstrating its requirement for high-frequency stimulation long-term potentiation in the CA1 hippocampus in adult mice, as well as contextual discrimination PMID:25043327
5. a novel role for R-Ras in promoting autoimmunity through negative regulation of natural regulatory T cell numbers by inhibiting the development of MHCII(low) DC with tolerogenic potential. PMID:24771856
6. Geranylgeranylation was required for membrane anchorage of Rras, whereas palmitoylation was required for exit from the Golgi in post-Golgi vesicle membranes and trafficking to the plasma membrane. PMID:22751447
7. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization. PMID:22897853
8. First demonstration of a role for R-Ras in cell-mediated immunity and further expand on the complexity of small G-protein signaling in dendritic cells. PMID:22174156
9. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. PMID:21572048
10. R-Ras is a small GTPase of the Ras family that regulates cell survival and integrin activity and is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. [R-ras] PMID:16286923
11. Data suggest that R-Ras and TC-21 play a role in facilitating branching and growth in early ureteric bud development, whereas H-Ras might favor cell migration and elongation of tubules, events that occur later in development. PMID:16467383
12. Rnd2 bound to Plexin-D1 in cortical neurons, and Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical neurons required Rnd2 and down-regulation of R-Ras activity. PMID:19136556

Show More

Hide All

UNIGENE: Mm.389894

KEGG: mmu:20130

STRING: 10090.ENSMUSP00000042150