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Recombinant Human Adhesion G protein-coupled receptor L1(ADGRL1),partial

Recombinant Human Adhesion G protein-coupled receptor L1(ADGRL1),partial

Code: CSB-EP013059HU3

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Size:

20ug100ug1mg

US$256

Quantity:

Express system: E.coli

Species: Homo sapiens (Human)

Tag Info: C-terminal 6xHis-tagged

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Product Details
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Target Background

Product Details

Abbreviation

Recombinant Human ADGRL1 protein, partial

Purity

≥85% as determined by SDS-PAGE.

Target Names

ADGRL1

Uniprot NO.

O94910

Research Area

Cancer

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

25-761aa

Mol. Weight

88.9 kDa

Protein Length

Partial

Tag Info

C-terminal 6xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

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Datasheet & COA

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Target Background

Function(From Uniprot)

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis.

Gene References into Functions

alterations in latrophilin expression occur in AML cells expressing P-gp PMID:29938681
Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human acute myeloid leukaemia PMID:27322212
A single SNP in LPHN1 (rs3810256) was identified, with the minor allele increasing the risk of asthma. PMID:27325752
In this article they evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex. PMID:20971062

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome.

Protein Families

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily

Database Links

HGNC: 20973

UNIGENE: Hs.94229

KEGG: hsa:22859

STRING: 9606.ENSP00000340688

OMIM: 616416

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