LPHN1 Antibody

Code: CSB-PA008270

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: IF, ELISA

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Target Background

Product Details

Uniprot NO.

O94910

Target Names

ADGRL1

Alternative Names

Calcium independent alpha latrotoxin receptor 1 antibody; Calcium-independent alpha-latrotoxin receptor 1 antibody; CIRL-1 antibody; CIRL1 antibody; CL1 antibody; CLIBA antibody; G protein-coupled receptor for alpha-Latrotoxin antibody; KIAA0821 antibody; Latrophilin 1 antibody; Latrophilin-1 antibody; Latrophilin1 antibody; LEC2 antibody; Lectomedin 2 antibody; Lectomedin-2 antibody; LPHN 1 antibody; LPHN1 antibody; LPHN1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human Latrophilin-1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

IF, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis.

Gene References into Functions

alterations in latrophilin expression occur in AML cells expressing P-gp PMID:29938681
Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human acute myeloid leukaemia PMID:27322212
A single SNP in LPHN1 (rs3810256) was identified, with the minor allele increasing the risk of asthma. PMID:27325752
In this article they evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex. PMID:20971062

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome.

Protein Families

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily

Database Links

HGNC: 20973

UNIGENE: Hs.94229

KEGG: hsa:22859

STRING: 9606.ENSP00000340688

OMIM: 616416

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