Home
Product
Protein
Recombinant Proteins
Recombinant Sheep Follicle-stimulating hormone receptor (FSHR), partial

Recombinant Sheep Follicle-stimulating hormone receptor (FSHR), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

FSHR

Uniprot NO.

P35379

Species

Ovis aries (Sheep)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

G protein-coupled receptor for follitropin, the follicle-stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase. Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase. Isoform FSH-R3 may be involved in calcium signaling. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.

Gene References into Functions

BB mutation-induced attenuation of BMPR1B signaling led to an increased density of the FSH receptor and LH receptor and a concurrent reduction in apoptosis PMID:25948249
Combined effect analyses indicated an extremely significant interaction between the random combinations of BMPR-IB, BMP-15 and FSHR genes on litter size. PMID:25993301
molecular cloning and characterization results identified a synonymous mutation in the ovine FSHR gene to be significantly associated with the litter size. PMID:25103022
Single nucleotide polymorphisms of 5' regulatory region of follicle-stimulating hormone receptor (FSHR) gene were detected in two high prolificacy sheep breeds and two low prolificacy sheep breeds. PMID:21725846

Hide All

Subcellular Location

[Isoform FSH-R1]: Cell membrane; Multi-pass membrane protein.; [Isoform FSH-R2]: Cell membrane; Multi-pass membrane protein.; [Isoform FSH-R3]: Cell membrane; Single-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily

Tissue Specificity

Isoform FSH-R3 is expressed in ovary and testis, but not in kidney (at protein level).

Database Links

UNIGENE: Oar.372

KEGG: oas:443299

Promotions