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Recombinant Schizosaccharomyces pombe DNA damage-binding protein 1 (ddb1), partial

Recombinant Schizosaccharomyces pombe DNA damage-binding protein 1 (ddb1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ddb1

Uniprot NO.

O13807

Alternative Names

ddb1; SPAC17H9.10cDNA damage-binding protein 1; Damage-specific DNA-binding protein 1

Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Source

Yeast

Expression Region

1-1072

Target Protein Sequence

MTYVTYLHKP SSIRNAVFCK FVNASSWNVI VAKVNCLEVY SYENNRLCLI TSANIFAKIV NVKAFKPVSS PTDHIIVATD SFRYFTLFWD ANDNTVSNGI KIQDCSERSL RESQSGPLLL VDPFQRVICL HVYQGLLTII PIFKSKKRFM TSHNNPSLHD NFSVRIQELN VVDIAMLYNS SRPSLAVLYK DSKSIVHLST YKINVREQEI DEDDVVCHDI EEGKLIPSEN GGVFVFGEMY VYYISKDIQV SKLLLTYPIT AFSPSISNDP ETGLDSSIYI VADESGMLYK FKALFTDETV SMELEKLGES SIASCLIALP DNHLFVGSHF NNSVLLQLPS ITKNNHKLEI LQNFVNIAPI SDFIIDDDQT GSSIITCSGA YKDGTLRIIR NSINIENVAL IEMEGIKDFF SVSFRANYDN YIFLSLICET RAIIVSPEGV FSANHDLSCE ESTIFVSTIY GNSQILQITT KEIRLFDGKK LHSWISPMSI TCGSSFADNV CVAVAGGLIL FFEGITEVGR YQCDTEVSSL CFTEENVVYV GLWSADIIML TYCQDGISLT HSLKLTDIPR SIVYSQKYGD DGGTLYVSTN NGYVLMFNFQ NGQVIEHSLR RNQLGVAPII LKHFDSKEKN AIFALGEKPQ LMYYESDKLV ITPLSCTEML NISSYVNPSL GVNMLYCTNS YISLAKMSEI RSLNVQTVSV KGFPRRICSN SLFYFVLCMQ LEESIGTQEQ RLLSFLRVYE KNTLSEIAHH KFNEYEMVES IILMNDDKRV VVGTGFNFPD QDAPDSGRLM VFEMTSDNNI EMQAEHKVQG SVNTLVLYKH LIVAGINASV CIFEYEHGTM HVRNSIRTPT YTIDISVNQD EIIAADLMKS ITVLQFIDDQ LIEVARDYHP LWATSVEILS ERKYFVTEAD GNAVILLRDN VSPQLSDRKK LRWYKKFYLG ELINKTRHCT FIEPQDKSLV TPQLLCATVD GSLMIVGDAG MSNTPLLLQL QDNIRKVIPS FGGLSHKEWK EYRGENETSP SDLIDGSLIE SILGLREPIL NEIVNGGHEG TKLDISVQDL KSIIENLEKL HP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Component of an E3 ubiquitin-protein ligase that includes cul4. Required for ubiquitination and the subsequent degradation of the DNA replication licensing factor cdt1 and of the ribonucleotide reductase inhibitor spd1. Also required for transcription-coupled nucleotide excision repair.

Gene References into Functions

Epe1 is the sole target of the Cul4-Ddb1(Cdt)2 complex whose destruction is necessary for the preservation of heterochromatin. PMID:21215368
Ddb1, along with Cullin 4 and the signalosome, constitute a major pathway controlling genome stability, repair, and differentiation via ribonucleotide reductase regulation. PMID:15805471
Data demonstrate that Cdt2, an unstable WD40 protein, is a regulatory subunit of Pcu4-Ddb1-CSN ubiquitin ligase PMID:16252005
We show that Cdt2 and Ddb1 are needed for cell-cycle changes in Cdt1 levels in the absence of DNA damage. PMID:17039252
These data indicate that the DDB-box is another common motif which defines adaptor proteins for DDB1/cullin 4 ubiquitin ligases. PMID:18794354