ddb1 Antibody

Code: CSB-PA006581XA01SXV

Rate （N/A）
Review （0）

Size:

0.1ml

0.1ml1ml

US$Enquire

Quantity:

Species Reactivity: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

Send an Inquiry

Start an on-line Chat

Online ordering is currently available for U.S. customers only. For orders outside the U.S., please kindly submit an inquiry or start a chat with us.

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot NO.

O13807

Target Names

ddb1

Alternative Names

ddb1 antibody; SPAC17H9.10cDNA damage-binding protein 1 antibody; Damage-specific DNA-binding protein 1 antibody

Raised in

Rabbit

Species Reactivity

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Immunogen

Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) ddb1 protein

Immunogen Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

Antibody FAQs

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Component of an E3 ubiquitin-protein ligase that includes cul4. Required for ubiquitination and the subsequent degradation of the DNA replication licensing factor cdt1 and of the ribonucleotide reductase inhibitor spd1. Also required for transcription-coupled nucleotide excision repair.

Gene References into Functions

Epe1 is the sole target of the Cul4-Ddb1(Cdt)2 complex whose destruction is necessary for the preservation of heterochromatin. PMID:21215368
Ddb1, along with Cullin 4 and the signalosome, constitute a major pathway controlling genome stability, repair, and differentiation via ribonucleotide reductase regulation. PMID:15805471
Data demonstrate that Cdt2, an unstable WD40 protein, is a regulatory subunit of Pcu4-Ddb1-CSN ubiquitin ligase PMID:16252005
We show that Cdt2 and Ddb1 are needed for cell-cycle changes in Cdt1 levels in the absence of DNA damage. PMID:17039252
These data indicate that the DDB-box is another common motif which defines adaptor proteins for DDB1/cullin 4 ubiquitin ligases. PMID:18794354