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Recombinant Saccharomyces cerevisiae Hsp90 co-chaperone Cdc37 (CDC37), partial

Recombinant Saccharomyces cerevisiae Hsp90 co-chaperone Cdc37 (CDC37), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CDC37

Uniprot NO.

P06101

Alternative Names

CDC37; SMO1; YDR168W; YD9489.03Hsp90 co-chaperone Cdc37; Cell division control protein 37; Hsp90 chaperone protein kinase-targeting subunit

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Source

Yeast

Expression Region

1-506

Target Protein Sequence

MAIDYSKWDK IELSDDSDVE VHPNVDKKSF IKWKQQSIHE QRFKRNQDIK NLETQVDMYS HLNKRVDRIL SNLPESSLTD LPAVTKFLNA NFDKMEKSKG ENVDPEIATY NEMVEDLFEQ LAKDLDKEGK DSKSPSLIRD AILKHRAKID SVTVEAKKKL DELYKEKNAH ISSEDIHTGF DSSFMNKQKG GAKPLEATPS EALSSAAESN ILNKLAKSSV PQTFIDFKDD PMKLAKETEE FGKISINEYS KSQKFLLEHL PIISEQQKDA LMMKAFEYQL HGDDKMTLQV IHQSELMAYI KEIYDMKKIP YLNPMELSNV INMFFEKVIF NKDKPMGKES FLRSVQEKFL HIQKRSKILQ QEEMDESNAE GVETIQLKSL DDSTELEVNL PDFNSKDPEE MKKVKVFKTL IPEKMQEAIM TKNLDNINKV FEDIPIEEAE KLLEVFNDID IIGIKAILEN EKDFQSLKDQ YEQDHEDATM ENLSLNDRDG GGDNHEEVKH TADTVD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Involved in both the HOG and the PKC MAP kinase signaling cascade necessary for adaptation to stress conditions due to high osmolarity or cell wall perturbation.

Gene References into Functions

During cell wall stress, the interaction between Cdc37p, Hog1p, and Hsp90 is crucial for Slt2p-dependent downstream responses to high osmotic and cell wall stress, respectively. PMID:17220467
Cdc37 has a general role in kinome biogenesis PMID:17242065
Kss1p interacts physically with Cdc37p PMID:17451450
There are at least 38 genes having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37. PMID:18075309
Cdc37p is a part of chaperone system that determins molybdate resistance in Saccharomyces cerevisiae. PMID:19399909