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Recombinant Saccharomyces cerevisiae E3 SUMO-protein ligase SIZ2 (NFI1), partial

Recombinant Saccharomyces cerevisiae E3 SUMO-protein ligase SIZ2 (NFI1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

NFI1

Purity

>85% (SDS-PAGE)

Target Names

NFI1

Uniprot NO.

Q12216

Alternative Names

NFI1; SIZ2; YOR156C; E3 SUMO-protein ligase SIZ2; EC 2.3.2.-; E3 SUMO-protein transferase SIZ2; SAP and Miz-finger domain-containing protein 2

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Source

Yeast

Expression Region

1-726

Target Protein Sequence

MASVMSNNNN NNNNNNASYM FTNPLSNTGG GLINEIKDAI NEMEQLKVLE LKQICKSLDL SITGKKAVLQ DRIKQFLRKS CDIGHIDPWR PKAIKILIAK VRINSSLPKY STLWETLKTG AFKHPVASGQ LPVTALQSTA LPPYSQQQAL AYSFTSPFYK PIVQIPDANK KLKQSAGRGC TKMKFKVSKS NHDLLKSNKS YKLYLFSGFS IPFIYETVGH EAIDFPYPCE LVFNGTKLED NVKGLKKQNG TGNPANLTPY LKVPTEMNHL DLHYLNIDKE YSISCFIVEV FSPEALLGKI LKRPKIIKQA TTAYIKRTLN EQDDDDIITT STVLSLQCPI SCTRMKYPAK TDQCKHIQCF DALWFLHSQS QVPTWQCPIC QHPIKFDQLK ISEFVDNIIQ NCNEDVEQVE ISVDGSWKPI HNSSAVITDT VNQNHSVKNE NQGTVKQEQD YDSRNAFDTN LRNGSNHNEP EIISLDSSDD EAFIPASKSF PTHVNPRNDQ LRADIFPSES EGSSDYNPNH TSTPKGSPTM DQDNYQDAFQ MRSFLNQGAT TNINDTPTNN SSINSFVTAT NGDSRIFYNR GPSTPLLPAV LQNLTNQTEA QRNPYGPNYN TTAQDRNLLG IEGDLPPIPP VDPNSEAETE LPTRTTSAAH LPPYIHVSTS GHGDDGKIRK RRHSNVSIYI PKNPYATLMK RRPQANHAIM NKTLAQTNDF NTSAQDNSEV VDLTSD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

May act as an E3 ligase mediating SUMO/Smt3 attachment to septins. May be involved in chromosome maintenance.

Gene References into Functions

double-strand break relocation to the nuclear envelope depends on SUMOylation mediated by the E3 ligases Siz2 and Mms21 PMID:27056668
The sumoylating activity of Siz2 at the nuclear periphery acts to maintain a balance of sumoylation that supports the localization of Sir2/Sir4 to these silent regions. PMID:22345352
The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. PMID:21666682

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Subcellular Location

Nucleus.

Protein Families

PIAS family

Database Links

KEGG: sce:YOR156C

STRING: 4932.YOR156C

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