NFI1 Antibody

Code: CSB-PA618581XA01SVG

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q12216

Target Names

NFI1

Alternative Names

NFI1 antibody; SIZ2 antibody; YOR156C antibody; E3 SUMO-protein ligase SIZ2 antibody; EC 2.3.2.- antibody; E3 SUMO-protein transferase SIZ2 antibody; SAP and Miz-finger domain-containing protein 2 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) NFI1 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

May act as an E3 ligase mediating SUMO/Smt3 attachment to septins. May be involved in chromosome maintenance.

Gene References into Functions

double-strand break relocation to the nuclear envelope depends on SUMOylation mediated by the E3 ligases Siz2 and Mms21 PMID:27056668
The sumoylating activity of Siz2 at the nuclear periphery acts to maintain a balance of sumoylation that supports the localization of Sir2/Sir4 to these silent regions. PMID:22345352
The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast. PMID:21666682

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Subcellular Location

Nucleus.

Protein Families

PIAS family

Database Links

KEGG: sce:YOR156C

STRING: 4932.YOR156C

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