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Recombinant Saccharomyces cerevisiae Dynamin-related protein DNM1 (DNM1), partial

Recombinant Saccharomyces cerevisiae Dynamin-related protein DNM1 (DNM1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

DNM1

Uniprot NO.

P54861

Alternative Names

DNM1; YLL001W; L1381Dynamin-related protein DNM1; EC 3.6.5.5

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Source

Yeast

Expression Region

1-757

Target Protein Sequence

MASLEDLIPT VNKLQDVMYD SGIDTLDLPI LAVVGSQSSG KSSILETLVG RDFLPRGTGI VTRRPLVLQL NNISPNSPLI EEDDNSVNPH DEVTKISGFE AGTKPLEYRG KERNHADEWG EFLHIPGKRF YDFDDIKREI ENETARIAGK DKGISKIPIN LKVFSPHVLN LTLVDLPGIT KVPIGEQPPD IEKQIKNLIL DYIATPNCLI LAVSPANVDL VNSESLKLAR EVDPQGKRTI GVITKLDLMD SGTNALDILS GKMYPLKLGF VGVVNRSQQD IQLNKTVEES LDKEEDYFRK HPVYRTISTK CGTRYLAKLL NQTLLSHIRD KLPDIKTKLN TLISQTEQEL ARYGGVGATT NESRASLVLQ LMNKFSTNFI SSIDGTSSDI NTKELCGGAR IYYIYNNVFG NSLKSIDPTS NLSVLDVRTA IRNSTGPRPT LFVPELAFDL LVKPQIKLLL EPSQRCVELV YEELMKICHK CGSAELARYP KLKSMLIEVI SELLRERLQP TRSYVESLID IHRAYINTNH PNFLSATEAM DDIMKTRRKR NQELLKSKLS QQENGQTNGI NGTSSISSNI DQDSAKNSDY DDDGIDAESK QTKDKFLNYF FGKDKKGQPV FDASDKKRSI AGDGNIEDFR NLQISDFSLG DIDDLENAEP PLTEREELEC ELIKRLIVSY FDIIREMIED QVPKAVMCLL VNYCKDSVQN RLVTKLYKET LFEELLVEDQ TLAQDRELCV KSLGVYKKAA TLISNIL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1.

Gene References into Functions

A double deletion mutant in which two essential components of the fission and fusion machinery, Dnm1 and Mgm1, are simultaneously ablated are characterized by impaired respiration and a decrease in mitophagy and replicative lifespan PMID:25601284
the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for association with the mitochondrial adaptor Mdv1 PMID:23148233
The de novo synthesis of peroxisomes is independent of the GTPases Vps1p and Dnm1p, two proteins required for peroxisome fission. PMID:20655617
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. PMID:21149566
Recruitment of Dnm1p to mitochondria is disrupted in mdv1delta caf4delta yeast, demonstrating that Mdv1p and Caf4p are molecular adaptors that recruit Dnm1p to mitochondrial fission sites PMID:16009724
dynamic interactions between Mdv1 and Dnm1 play a key role in division by regulating Dnm1 self-assembly PMID:16272155
Dnm1p dimers are initially recruited to the membrane via interaction with Mdv1p.Fis1p complexes PMID:16601120
Data suggest that Caf4p and Fis1, but not Mdv1, play a role in determining the polarized localization of those Dnm1p clusters that are not immediately involved in the mitochondrial fission process. PMID:16835275
Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. PMID:16968746
We demonstrate that the dynamin-related protein 1 (Dnm1p), a mitochondrial fission protein conserved from yeast to humans, affects ageing in the two model systems we studied, Podospora anserina and Saccharomyces cerevisiae. PMID:17173038
Thus, our studies have revealed an additional role for Dnm1p in mitochondrial transmission through its interaction with Num1p, thereby providing a link between mitochondrial division and inheritance. PMID:17336903
the concave surface of the Fis1 tetratricopeptide repeat-like domain is evolutionarily conserved to bind the dynamin-like GTPase Dnm1 and not Mdv1 as previously predicted PMID:17884824
Woronin bodies emerge after the formation of a HEX1 core crystal within peroxisomes followed by Vps1p- and Dnm1p-mediated fission PMID:18435762
findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p PMID:18445678
Mdv1 played a postmitochondrial targeting role in division by interacting & coassembling with the GTP-bound form of Dnm1; this regulated interaction nucleated & promoted self-assembly of Dnm1 into helical structures which drive membrane scission PMID:19679814

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Subcellular Location

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasm, localizes to the cytoplasmic outer membrane of mitochondria.

Protein Families

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family

Database Links

KEGG: sce:YLL001W

STRING: 4932.YLL001W

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