DNM1 Antibody

Code: CSB-PA345810XA01SVG

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0.1ml

0.1ml1ml

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Species Reactivity: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P54861

Target Names

DNM1

Alternative Names

DNM1 antibody; YLL001W antibody; L1381Dynamin-related protein DNM1 antibody; EC 3.6.5.5 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) DNM1 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1.

Gene References into Functions

A double deletion mutant in which two essential components of the fission and fusion machinery, Dnm1 and Mgm1, are simultaneously ablated are characterized by impaired respiration and a decrease in mitophagy and replicative lifespan PMID:25601284
the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for association with the mitochondrial adaptor Mdv1 PMID:23148233
The de novo synthesis of peroxisomes is independent of the GTPases Vps1p and Dnm1p, two proteins required for peroxisome fission. PMID:20655617
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. PMID:21149566
Recruitment of Dnm1p to mitochondria is disrupted in mdv1delta caf4delta yeast, demonstrating that Mdv1p and Caf4p are molecular adaptors that recruit Dnm1p to mitochondrial fission sites PMID:16009724
dynamic interactions between Mdv1 and Dnm1 play a key role in division by regulating Dnm1 self-assembly PMID:16272155
Dnm1p dimers are initially recruited to the membrane via interaction with Mdv1p.Fis1p complexes PMID:16601120
Data suggest that Caf4p and Fis1, but not Mdv1, play a role in determining the polarized localization of those Dnm1p clusters that are not immediately involved in the mitochondrial fission process. PMID:16835275
Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. PMID:16968746
We demonstrate that the dynamin-related protein 1 (Dnm1p), a mitochondrial fission protein conserved from yeast to humans, affects ageing in the two model systems we studied, Podospora anserina and Saccharomyces cerevisiae. PMID:17173038
Thus, our studies have revealed an additional role for Dnm1p in mitochondrial transmission through its interaction with Num1p, thereby providing a link between mitochondrial division and inheritance. PMID:17336903
the concave surface of the Fis1 tetratricopeptide repeat-like domain is evolutionarily conserved to bind the dynamin-like GTPase Dnm1 and not Mdv1 as previously predicted PMID:17884824
Woronin bodies emerge after the formation of a HEX1 core crystal within peroxisomes followed by Vps1p- and Dnm1p-mediated fission PMID:18435762
findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p PMID:18445678
Mdv1 played a postmitochondrial targeting role in division by interacting & coassembling with the GTP-bound form of Dnm1; this regulated interaction nucleated & promoted self-assembly of Dnm1 into helical structures which drive membrane scission PMID:19679814

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Subcellular Location

Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasm, localizes to the cytoplasmic outer membrane of mitochondria.

Protein Families

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family

Database Links

KEGG: sce:YLL001W

STRING: 4932.YLL001W

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