Recombinant Rat Tonin (Klk2)

Baculovirus

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Klk2

Uniprot NO.

P00759

Alternative Names

Klk2; Klk-2; Ton; Tonin; EC 3.4.21.35; Esterase 1; Glandular kallikrein-2; rGK-2; RSKG-5; S2 kallikrein

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

25-259

Target Protein Sequence

IVGGYK CEKNSQPWQV AVINEYLCGG VLIDPSWVIT AAHCYSNNYQ VLLGRNNLFK DEPFAQRRLV RQSFRHPDYI PLIVTNDTEQ PVHDHSNDLM LLHLSEPADI TGGVKVIDLP TKEPKVGSTC LASGWGSTNP SEMVVSHDLQ CVNIHLLSNE KCIETYKDNV TDVMLCAGEM EGGKDTCAGD SGGPLICDGV LQGITSGGAT PCAKPKTPAI YAKLIKFTSW IKKVMKENP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen.

Gene References into Functions

the environment of tonin abundance may increase N-domain ACE activity liberated by a secretase able to cleave somatic ACE. PMID:26216430
Tonin in the brain may represent an alternative pathway for angiotensin II generation with effects on the cardiovascular system. PMID:20180641
expression in the rat brain and mediation of the central production of angiotensin II PMID:12044607
tonin may play a role in the process of heart hypertrophy PMID:12543632
KLK2 rat gene was expressed at high levels in the submandibular glands of transgenic mice. PMID:17366701