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Recombinant Rat T-cell surface antigen CD2 (Cd2), partial

Recombinant Rat T-cell surface antigen CD2 (Cd2), partial

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cd2

Uniprot NO.

P08921

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Gene References into Functions

At temperatures above approx 68 degrees C, a partially folded state of CD2-1 (H state) with a distinct secondary structure, involving largely exposed aromatic and hydrophobic residues and a substantially perturbed tertiary structure, is observed. PMID:11939369
Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Review. PMID:12369898
Data show that designed cyclic peptides with beta-turn structure have the ability to modulate the CD2-CD58 interaction, which is critical for an immune response. PMID:15233784

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Database Links

UNIGENE: Rn.10328

KEGG: rno:497761

STRING: 10116.ENSRNOP00000021268

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