Recombinant Rat Relaxin receptor 1 (Rxfp1), partial

1. Data indicate that knee passive range of motion (ROM), relaxin receptor isoforms Rxfp1 and Rxfp2 expression were significantly reduced following treatment with testosterone, and androgen antagonist flutamide antagonized the testosterone effect. PMID:24642882
2. RXFP1 & RXFP2 up-regulation by progesterone and estrogen could provide the basis for the reported increase in knee laxity while down-regulation of these receptor isoforms by testosterone could explain low incidence of non-contact knee injury in male. PMID:24465164
3. RXFP1 was predominantly localized to the tunica media vascular smooth muscle cells in the uterine artery. Highest expression of Rxfp1 in the uterine artery occurred in estrus and early pregnancy. PMID:22744867
4. H3 relaxin exerts antifibrotic actions via RXFP1 receptor PMID:21229994
5. investigation of expression of RXFP1 in myometrium during gestation; the down-regulation of RXFP1 expression that occurs in late gestation correlates well with progesterone withdrawal PMID:20686183
6. investigation of expression of RXFP1 in uterine tissues before, during, and after pregnancy; fetal-placental unit appears involved in regulation of expression of RXFP1; down-regulation of RXFP1 expression occurs in late gestation PMID:20686184
7. Uncovered is a pre-assembled, constitutively active G-protein-coupled receptor signalosome, that couples the relaxin receptor, relaxin family peptide receptor 1 (RXFP1), to cAMP following receptor stimulation with sub-picomolar concentrations of peptide. PMID:20664520
8. mouse and rat LGR7 are the relaxin receptors in these species PMID:15566402
9. Mouse and rat LGR7 were able to bind to and be activated by relaxin ligands PMID:15956680
10. LGR7-Truncate is potentially an endogenous regulator of LGR7 signaling PMID:15956683
11. both LGR7 and LGR8 are expressed in activated hepatic stellate cells and cirrhotic liver PMID:15956705
12. High densities of LGR7 mRNA hybridization were detected in deep layers of neocortex, hypothalamic paraventricular and supraoptic nuclei and within hippocampal subiculum and CA3, the basolateral amygdala and subfornical organ PMID:15956709
13. Leucine-rich-repeat-containing G-protein-coupled receptor-7 mRNA was expressed by neurons in several brain regions, including the olfactory bulb, cerebral cortex, thalamus, hippocampus, hypothalamus, midbrain, pons and medulla. PMID:16725278
14. derivatives of LGR7 relaxin receptor have a dose dependent affect on the enyzymatic activity of relaxin-sensitive adenylate cyclase PMID:16776079
15. Lgr7 and Lgr8 are upregulated in response to a reduction in uteroplacental blood flow in rats. PMID:17524297
16. G-protein coupled receptor RXFP1, previously known as LGR7, is widely distributed throughout the male rat reproductive tract and may be important in regulation of spermatogenesis. PMID:17623071

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UNIGENE: Rn.109230

KEGG: rno:295144

STRING: 10116.ENSRNOP00000033541