Recombinant Rat Parathyroid hormone (Pth)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Pth

Uniprot NO.

P04089

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

32-115

Target Protein Sequence

AVSEIQLMH NLGKHLASVE RMQWLRKKLQ DVHNFVSLGV QMAAREGSYQ RPTKKEENVL VDGNSKSLGE GDKADVDVLV KAKSQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

Please provide the certificate of analysis, as well as a detailed list of what is in the
storage buffer, and the method of growing and purifying the PTH.

Thanks for your inquiry. Now we don't have COA, here attach the data sheet for your reference.
Buffer:Tris-based buffer, pH 8.0, 50% glycerol ( If you have special request on the buffer, pls tell us, we will check if we could meet your request.)
The purify method is Ni column affinity chromatography.

Target Background

Function(From Uniprot)

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

Gene References into Functions

PTHrP and PTH mediate wasting through a common mechanism involving PTHR. PMID:26669699
our data demonstrate that PTH activation of nuclear receptor-associated protein 1 is essential for the effect of PTH to increase FGF23 levels. PMID:24940803
data support a link between PTH regulating HDAC4 phosphorylation by PKA, trafficking, partial degradation, and the control of MMP-13 transcription through association with Runx2 PMID:24904057
Mg reduces PTH secretion mainly when a moderate low calcium concentration is present; Mg also modulates parathyroid glands function through upregulation of the key cellular receptors CaR, VDR and FGF23/Klotho system. PMID:24103811
The persistence of the phosphaturic response to PTH occurs through posttranscriptional mechanisms. PMID:23344572
The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activity. PMID:21209610
Data suggest that a high concentration of PTH(1-34)-induced cytotoxicity and apoptosis in PC12 cells was associated with upregulation of ERK and p38 through a mitochondria-mediated apoptotic pathway. PMID:20971569
Study indicates an influence of sex on PTH molecular form secretion or metabolism. PMID:20627105
Modulation of integrin expression in osteoblastic cells by PTH is likely to be indirect, and phenotypic expression of integrin subtypes is part of the cascade of events that lead to PTH (1-34) mediated osteoblast differentiation. PMID:11746505
New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells PMID:11956184
alterations in PI3K activity in response to parathyroid hormone with aging PMID:12581861
PTH or PTHrP can exert anabolic effects in the skeleton. PMID:12631114
that periosteal and endosteal osteoblastic cell populations exhibit metabolic differences in their extracellular matrix responses to PTH PMID:14514685
the parathyroid hormone-Smad3 axis may have a role in the bone anabolic action of PTH PMID:14517210
PTH and mechanical stimulation on trabecular bone formation rate suggest a potential benefit for combined PTH administration and exercise in the treatment of osteoporosis. PMID:14672346
Rho and Rho kinase are an important component of PTH signaling in osteoblastic cells PMID:15476589
Combinations of radioprotectors may achieve their beneficial additive effects in the growth plate by decreasing the usual early drop in parathyroid hormone-related protein and parathyroid hormone receptor 1 after irradiation PMID:16494524
Calcium, phosphate & uremia determine parathyroid hormone mRNA stability through binding of protective factors adenosine-uridine rich binding factor 1 & Up-stream of N-ras & recruitment of degradation complex that cleaves parathyroid hormone mRNA[review] PMID:17565271
FGF23 suppressed both parathyroid hormone (PTH) secretion and PTH gene expression PMID:17992255
IL-18 is regulated by parathyroid hormone and is required for its bone anabolic actions PMID:18165223
These data indicate a novel role for KSRP in parathyroid hormone gene expression. PMID:18583400
Phosphate overload and normal parathyroid hormone infusion induced phenotypic changes in vascular smooth muscle cells, as evidenced by upregulated aortic expression of Runx2. PMID:19075196
Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in chronic kidney disease. PMID:19129257
without altering the gross chromatin structure, PTH stimulates acetylation of histones H3 and H4 via recruitment of p300 to Runx2 bound to the MMP-13 promoter, resulting in gene activation PMID:19423655
estrogens regulate PTH indirectly, possibly through FGF23 PMID:19628670
Parathyroid hormone (PTH) suppresses rat PTH/PTH-related protein receptor gene promoter PMID:11554727