Made-to-order (12-14 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Value-added Deliverables
① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Gene References into Functions
PTHrP and PTH mediate wasting through a common mechanism involving PTHR.PMID:26669699
our data demonstrate that PTH activation of nuclear receptor-associated protein 1 is essential for the effect of PTH to increase FGF23 levels.PMID:24940803
data support a link between PTH regulating HDAC4 phosphorylation by PKA, trafficking, partial degradation, and the control of MMP-13 transcription through association with Runx2PMID:24904057
Mg reduces PTH secretion mainly when a moderate low calcium concentration is present; Mg also modulates parathyroid glands function through upregulation of the key cellular receptors CaR, VDR and FGF23/Klotho system.PMID:24103811
The persistence of the phosphaturic response to PTH occurs through posttranscriptional mechanisms.PMID:23344572
The secretory response of parathyroid hormone to acute hypocalcemia in vivo is independent of parathyroid glandular sodium/potassium-ATPase activity.PMID:21209610
Data suggest that a high concentration of PTH(1-34)-induced cytotoxicity and apoptosis in PC12 cells was associated with upregulation of ERK and p38 through a mitochondria-mediated apoptotic pathway.PMID:20971569
Study indicates an influence of sex on PTH molecular form secretion or metabolism.PMID:20627105
Modulation of integrin expression in osteoblastic cells by PTH is likely to be indirect, and phenotypic expression of integrin subtypes is part of the cascade of events that lead to PTH (1-34) mediated osteoblast differentiation.PMID:11746505
New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cellsPMID:11956184
alterations in PI3K activity in response to parathyroid hormone with agingPMID:12581861
PTH or PTHrP can exert anabolic effects in the skeleton.PMID:12631114
that periosteal and endosteal osteoblastic cell populations exhibit metabolic differences in their extracellular matrix responses to PTHPMID:14514685
the parathyroid hormone-Smad3 axis may have a role in the bone anabolic action of PTHPMID:14517210
PTH and mechanical stimulation on trabecular bone formation rate suggest a potential benefit for combined PTH administration and exercise in the treatment of osteoporosis.PMID:14672346
Rho and Rho kinase are an important component of PTH signaling in osteoblastic cellsPMID:15476589
Combinations of radioprotectors may achieve their beneficial additive effects in the growth plate by decreasing the usual early drop in parathyroid hormone-related protein and parathyroid hormone receptor 1 after irradiationPMID:16494524
Calcium, phosphate & uremia determine parathyroid hormone mRNA stability through binding of protective factors adenosine-uridine rich binding factor 1 & Up-stream of N-ras & recruitment of degradation complex that cleaves parathyroid hormone mRNA[review]PMID:17565271
FGF23 suppressed both parathyroid hormone (PTH) secretion and PTH gene expressionPMID:17992255
IL-18 is regulated by parathyroid hormone and is required for its bone anabolic actionsPMID:18165223
These data indicate a novel role for KSRP in parathyroid hormone gene expression.PMID:18583400
Phosphate overload and normal parathyroid hormone infusion induced phenotypic changes in vascular smooth muscle cells, as evidenced by upregulated aortic expression of Runx2.PMID:19075196
Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in chronic kidney disease.PMID:19129257
without altering the gross chromatin structure, PTH stimulates acetylation of histones H3 and H4 via recruitment of p300 to Runx2 bound to the MMP-13 promoter, resulting in gene activationPMID:19423655
estrogens regulate PTH indirectly, possibly through FGF23PMID:19628670
Parathyroid hormone (PTH) suppresses rat PTH/PTH-related protein receptor gene promoterPMID:11554727