Recombinant Rat Haptoglobin (Hp)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

P06866

Alternative Names

Hp; Ba1-647; Haptoglobin; Liver regeneration-related protein LRRG173) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

19-347

Target Protein Sequence

VE LGNDATDIED DSCPKPPEIA NGYVEHLVRY RCRQFYKLQT EGDGIYTLNS EKQWVNPAAG DKLPKCEAVC GKPKHPVDQV QRIIGGSMDA KGSFPWQAKM ISRHGLTTGA TLISDQWLLT TAQNLFLNHS ENATAKDIAP TLTLYVGKNQ LVEIEKVVLH PERSVVDIGL IKLKQKVLVT EKVMPICLPS KDYVAPGRMG YVSGWGRNVN FRFTERLKYV MLPVADQEKC ELHYEKSTVP EKKGAVSPVG VQPILNKHTF CAGLTKYEED TCYGDAGSAF AVHDTEEDTW YAAGILSFDK SCAVAEYGVY VRATDLKDWV QETMAKN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

Gene References into Functions

This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction. PMID:23172820
Vaccenic acid normalizes serum haptoglobin in obese/insulin resistant JCR:LA-cp rats PMID:22254015
activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator. PMID:20155810
Haptoglobin deficiency worsens intracerebral hemorrhage whereas haptoglobin overexpression alleviates intracerebral hemorrhage-mediated brain injury. PMID:20016097
Hp-mediated haemoglobin catabolism in lung cells may be an efficient mechanism to reduce oxidative damage associated with haemolysis PMID:11865979
Haptoglobin gene expression regulation PMID:11865981
Hp is transcriptionally modulated throughout prenatal hepatic development by fetal p53 protein. PMID:11991649
upregulated in reactive astrocytes after transient forebrain ischemia in rats PMID:12368655
Hp gene transcription is regulated by C/EBP alpha during normal liver development, whereas C/EBP beta is involved in the acute-phase response regulation during the later phase of differentiation and in the adult. PMID:16172914
Western blotting and enzyme-linked immunosorbent assay clearly showed a markedly increased level of Hp in the urine, but not in the serum, of the PHN animals. PMID:17616219
that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells. PMID:17910034
lamin components of the nuclear matrix form a network of functional, dynamic protein-protein and protein-Hp-S/MAR associations with multiple partners, and underline the involvement of PARP-1 in the regulation of haptoglobin gene transcription. PMID:19521970
Data concluded that haptoglobin gene up-regulation during chronic dietary restriction was regulated by different mechanisms than during the acute phase response. PMID:19545490