Hp Antibody

Code: CSB-PA17069A0Rb

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US$83

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Species Reactivity: Rat

Raised in: Rabbit

Application: ELISA, WB, IHC

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Target Background

Product Details

Uniprot NO.

P06866

Target Names

Alternative Names

Hp antibody; Ba1-647 antibody; Haptoglobin antibody; Liver regeneration-related protein LRRG173) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] antibody

Raised in

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant Rat Haptoglobin protein (19-346AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: Hp antibody at 2µg/ml + Rat live tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39, 43 kDa
Observed band size: 39 kDa
Immunohistochemistry of paraffin-embedded mouse liver tissue using CSB-PA17069A0Rb at dilution of 1:50

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Target Background

Function(From Uniprot)

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

Gene References into Functions

This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction. PMID:23172820
Vaccenic acid normalizes serum haptoglobin in obese/insulin resistant JCR:LA-cp rats PMID:22254015
activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator. PMID:20155810
Haptoglobin deficiency worsens intracerebral hemorrhage whereas haptoglobin overexpression alleviates intracerebral hemorrhage-mediated brain injury. PMID:20016097
Hp-mediated haemoglobin catabolism in lung cells may be an efficient mechanism to reduce oxidative damage associated with haemolysis PMID:11865979
Haptoglobin gene expression regulation PMID:11865981
Hp is transcriptionally modulated throughout prenatal hepatic development by fetal p53 protein. PMID:11991649
upregulated in reactive astrocytes after transient forebrain ischemia in rats PMID:12368655
Hp gene transcription is regulated by C/EBP alpha during normal liver development, whereas C/EBP beta is involved in the acute-phase response regulation during the later phase of differentiation and in the adult. PMID:16172914
Western blotting and enzyme-linked immunosorbent assay clearly showed a markedly increased level of Hp in the urine, but not in the serum, of the PHN animals. PMID:17616219
that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells. PMID:17910034
lamin components of the nuclear matrix form a network of functional, dynamic protein-protein and protein-Hp-S/MAR associations with multiple partners, and underline the involvement of PARP-1 in the regulation of haptoglobin gene transcription. PMID:19521970
Data concluded that haptoglobin gene up-regulation during chronic dietary restriction was regulated by different mechanisms than during the acute phase response. PMID:19545490