Recombinant Rat Follitropin subunit beta (Fshb)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Fshb

Uniprot NO.

P18427

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

21-130

Target Protein Sequence

SCELTNITIS VEKEECRFCI SINTTWCEGY CYTRDLVYKD PARPNTQKVC TFKELVYETI RLPGCARHSD SLYTYPVATE CHCGKCDSDS TDCTVRGLGP SYCSFGEMKE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

Gene References into Functions

Study in primary rat pituitary cells demonstrates that miR-186-5p regulates FSH secretion by directly targeting the FSHb 3' UTR. PMID:29534107
our results indicate that miR-21-3p and miR-433 can down-regulate the expression of FSHb by directly targeting the FSHb 3'UTR in rat primary pituitary cells. PMID:28402262
the upstream region of Fshb is susceptible to unsaturated long-chain fatty acids PMID:26853521
GnRH stimulation of Fshb expression is dependent on miR-132/212 and involves a SIRT1-FOXO1 pathway. PMID:25635942
FSH acutely regulated CCND2 expression through both PKA and PI3K signaling pathways during granulosa cell proliferation and also accelerated its ubiquitination-proteasomal degradation. PMID:23349233
Data suggest that FSH (Cga/FSHb) induces clock system in granulosa cells by up-regulation of connexin 43 expression; this suggests that gap junctions are implicated in circadian clock in peripheral oscillators besides central pacemaker. PMID:23299500
Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model. PMID:22249524
FSH autoantibody could cause the reduction of inhibin B, thereby inducing hypospermatogenesis via augment of spermatogenic cell apoptosis PMID:22564408
Novel findings supporting the role of FSH in primordial follicle survival through an action on apoptosis. PMID:22106407
These results show that the synthesis of FSH isoforms possessing alpha2,6-linked sialic acid is hormonally regulated in male rats. PMID:19464343
Data suggest that FSH beta subunit expression (and LH beta subunit expression) is regulated by DUSP1 expression (specifically in response to high-frequency GnRH pulses); this effect may occur in association with MAPK3/1 phosphorylation. PMID:21228211
A potential new regulatory mechanism of the FSH signalling pathway that could occur during maturation of testicular cells. PMID:20201104
Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. PMID:12145338
The regulation of FSHbeta is dependent on activin-mediated signaling factors in concert with pituitary-derived nuclear regulatory proteins. PMID:12554780
PACAP contributes to the selective regulation of FSHbeta expression during maturation in the male PMID:12646491
androgens acting directly on the pituitary increase FSH-beta and decrease LH-beta transcription. PMID:14512439
FSH enhances HIF-1 activity downstream of the PI 3-kinase/AKT/Rheb/mTOR pathway in GCs and HIF-1 activity is necessary for FSH to induce multiple follicular differentiation markers PMID:14982927
SMAD3 plays an important role in the synergistic effects of activin and gonadotropin-releasing hormone and demonstrate that this synergy is mediated by a palindromic cis-element located at -266/-259 of the rFSHbeta gene promoter PMID:15375186
Smad3 is not only sufficent but also necessary for activin-mediated regulation of FSHbeta promoter. PMID:15761025
oxidative stress induces apoptosis in preovulatory follicles and the antiapoptotic effect of FSH is mediated in part by stimulation of follicular GSH synthesis and suppression of ROS production PMID:16339198
Testosterone regulates FSHbeta transcription, in part, through modulation of various components of the activin-signaling system. PMID:17405825
The result found that pyramidal neurons from CA1 to CA4 region and granule neurons in dentate gyrus could express FSH and its receptor, majority of hippocampal neurons co-expressed FSH and its receptor, FSH and GnRH receptor. PMID:17674129
Smad3 and Pitx2 cooperate in stimulation of FSHbeta gene transcription. PMID:18022758
PI3-kinase may be involved in the negative regulation of alpha- and FSHbeta-subunit gene expression as well as cell proliferation. PMID:18206295
Dexamethasone (4 nM) for 3 weeks partially rescued LH beta/follicle-stimulating hormone beta cells. PMID:18363807