rat follicle-stimulating hormone,FSH ELISA Kit

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Code: CSB-E06869r

Rate （5.0）
Review （1）
Citation （149）

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Size:

96T,5×96T,10×96T

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Quantity:

Sample Types: serum, plasma, tissue homogenates

Detect Range: 0.17 mlU/ml-10 mlU/ml.

Sensitivity: 0.07 mlU/ml.

Trial Size:

24T ELISA Kit Trial Size (Only USD$150/ kit)
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Product Details

Alternative Names

FshbFollitropin subunit beta ELISA kit; Follicle-stimulating hormone beta subunit ELISA kit; FSH-B ELISA kit; FSH-beta ELISA kit; Follitropin beta chain ELISA kit

Abbreviation

FSH

Uniprot NO.

P18427

Species

Rattus norvegicus (Rat)

Sample Type

serum, plasma, tissue homogenates

Detection Range

0.17 mlU/ml-10 mlU/ml.

Sensitivity

0.07 mlU/ml.

Assay Time

1-5h

Sample Loading Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Signal Transduction

Assay Principle

quantitative
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Measurement

Competitive

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Troubleshooting and FAQs

ELISA kit FAQs

ELISA Data Analysis

ELISA Standard Curve & Curve Expert software

Description

The Rat follicle-stimulating hormone (FSH) ELISA Kit is designed for the quantitative determination of endogenic rat FSH concentrations in serum, plasma, or tissue homogenates. This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for FSH has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any FSH present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for FSH is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of FSH bound in the initial step. The color development is stopped and the intensity of the color is measured.

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Sample species : a:1:{i:0;a:2:{i:0;s:3:"Rat";i:1;s:0:"";}}

Sample type: a:1:{i:0;a:2:{i:0;s:5:"Serum";i:1;s:0:"";}}

Sample dilution: a:1:{i:0;a:2:{i:0;s:11:"No dilution";i:1;s:0:"";}}

Review: I used CSB-E06869r to detect normal (FSH) serum. The OD value of the standard curve was 0.0838, 0.2267, 0.5508, 0.9712, 1.1333, 1.3067, and the OD value of the sample (the sample OD can provide an approximate range) was 0.1-0.25.

By Anonymous

■ Q&A

1) What is the calibrator?
2) Is the calibration traceable to the RP-2 rat FSH?

Thanks for your inquiry. CSB-E06869r is designed for common rat and its standard is 293 cell-derived recombinant rat FSH protein.

Do sample diluents and wash buffers work the same? How to dilute serum sample for FSH ELISA kit?

Sample diluents and wash buffers have different functions. And the components in them are also different.
If your serum sample from rat is with high concentration, you could consider using the sample diluent. But you should determine the best dilution factor by doing a pre-experiment first.

Citations

Chronic Administration of High Doses of NandroloneDecanoate on the Pituitary-Gonadal Axis in Male Rats Alsi J. et al,/,2009
Alterations in gene expression and steroidogenesis in the testes of transient cerebral ischemia in male rats Zhao BH et al,/,2012
Evaluation of effects of repeated sevoflurane exposure on rat testicular tissue and reproductive hormones Kaya Z et al,/,2013
Hormonal and histological changes in the ovaries with high-doses of methylprednisolone administration for acute spinal cord injury: An experimental study Osmanaaolu MA et al,/,2013
Impact of 900 MHz electromagnetic field exposure on main male reproductive hormone levels: a Rattus norvegicus model Sepehrimanesh M et al,/,2013
Effects of the phytoestrogen genistein on the development of the reproductive system of Sprague Dawley rats Siti Rosmani Md Zin et al,/,2013
Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rat Karbalaei N, et al,/,2019
A Chinese herbal formula, Wuzi Yanzong Pill (), improves spermatogenesis by modulating the secretory function of Sertoli cells Xu YP et al,/,2014
A Survey of the Relationship Between Noised Pollution, Honey and Vitamin E and Plasma Level of Blood Sexual Hormones in Noise-Exposed Rats Asghar Rajabzadeh et al,/,2015
Effect of Excess Iodine on Oxidative StressMarkers, Steroidogenic-Enzyme Activities, Testicular Morphology, and Functions in Adult Male Rats Chakraborty A. et al,/,2015
Effect of honey on the reproductive system of male rat offspring exposed to prenatal restraint stress Haron MN. et al,/,2015
Evaluation of offspring sex ratio, sex hormones and antioxidant enzymes following exposure to methyl tertiary butyl ether in adult male Sprague-Dawley rats. Khalili L.et al,/,2015
Toxicological evaluation of isopropylparaben and isobutylparaben mixture in Sprague-Dawley rats following 28 days of dermal exposure Kim MJ. et al,/,2015
Honey and Vitamin E Restore the Plasma Level of Gonadal Hormones and Improve the Fertilization Capacity in Noise-Stressed Rats Rajabzadeh A.et al,/,2015
The Effect of Intraventricular Administration of Zinc on Serum LH, FSH, Prolactin, and Testosterone in Male Rats Shahraki M R.et al,/,2015
Mammary gland epithelial changes in thyroidectomized female rats Vasilios Pergialiotis et al,/,2015
Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood Ambrosetti V. et al,/,2016
Active immunization with GnRH-tandem-dimer peptide in young male rats reduces serum reproductive hormone concentrations, testicular development and spermatogenesis Han X F.et al,/,2016
Acetylshikonin from Zicao exerts antifertility effects at high dose in rats by suppressing the secretion of GTH. He Y.et al,/,2016
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms Ozlem Atli.et al,/,2016
Protective Antioxidant Efficiency of Garlic against Lead-Induced Renal and Testicular Toxicity in Adult Male Rats Salem NA.et al,/,2016
High-Cholesterol Diet Disrupts the Levels of Hormones Derived from Anterior Pituitary Basophilic Cells Yang J.et al,/,2016
Effect of Intravenous Administration of Cobalt Chloride to Horses on Clinical and Hemodynamic Variables Burns TA.et al,/,2017
Effect of amifostine on sperm DNA fragmentation and testes after radioiodine treatment Cigdem Cebi Sen.et al,/,2017
Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system D Fernandois.et al,/,2017
EFFECT OF ADDING DRIED GINGER RHIZOMES TO DIETS ON SEMEN QUALITY AND FERTILITY RATE IN AGED LOCAL COCKS UNDER EGYPTIAN HOT Ezzat, W.et al,/,2017
Restoration of Spermatogenesis Using a New Combined Herbal Formula of Epimedium koreanum Nakai and Angelica gigas Nakai in an Luteinizing HyunJun Park.et al,/,2017
Citalopram Induces Reproductive Toxicity in Male Rats Ilgin S.et al,/,2017
Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model Jae-Hwan Lee .et al,/,2017
Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism Li J.et al,/,2017
Alteration in follistatin gene expression detected in prenatally androgenized rats Marziyeh Salehi Jahromi.et al,/,2017
Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress Merve Baysa.et al,/,2017
Investigating the prenatal exposure of hydro-alcoholic extract of ginger on the function of Pituitary-Gonad axis in male mature offspring rats Nasim Zamani .et al,/,2017
Therapeutic effect of curcumin against nicotine-induced reproductive dysfunction in male rats Neveen A. Salem.et al,/,2017
How do vegetable oils (hazelnut and canola) affect the reproductive system in male rats? Bulent Kati.et al,/,2018
Genistein and daidzein treatments differently affect uterine homeostasis in the ovary-intact middle-aged rats Ivana Jari.et al,/,2018
Fructus Ligustri Lucidi modulates estrogen receptor expression with no uterotrophic effect in ovariectomized rats Tang YQ.et al,/,2018
Effects of chronic unpredictable mild stress on ovarian reserve in female rats: Feasibility analysis of a rat model of premature ovarian failure Xiao‑Yan Fu.et al,/,2018
Protective effects of persian honey, Apis Mellifera Meda Skorikov on side effects of chemotherapy and ischemia/reperfusion induced testicular injury Mohammadreza Gholami .et al,/,2018
TOXIC EFFECTS OF TRAZADONE ON MALE REPRODUCTIVE SYSTEM VIA DISRUPTING HYPOTHALAMIC-PITUITARY-TESTICULAR AXIS AND INDUCING TESTICULAR OXIDATIVE STRESS Sinem Ilgin.et al,/,2018
Depletion of follicles accelerated by combined exposure to phthalates and 4-vinylcyclohexene diepoxide, leading to premature ovarian failure in rats Dinh NamTran.et al,/,2018
Comparative study of the effect of taurine, caffeine, and /or paracetamol on male fertility and teratogenicity in rats Asmaa M.Kandil.et al,/,2018
The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome Seyed Hosein Abtahi-Eivari.et al,/,2018
Anti-hypercholesterolemic impacts of barley and date palm fruits on the ovary of Wistar albino rats and their offspring Hassan I.H.El-Sayyad.et al,/,2018
Amelioration of diabetes‐induced testicular and sperm damage in rats by cerium oxide nanoparticle treatment Tayebe Artimani.et al,/,2018
Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats Zaid SSM, et al ,/,2018
The Effect of Electromagnetic Fields of Extremely Low Frequency 30 Hz on Rat Ovaries Alekperov SI, et al,/,2019
Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats Zaid SSM, et al ,/,2018
Impact of Sleep Deprivation on the Hypothalamic-Pituitary-Gonadal Axis and Erectile Tissue Lee DS, et al,/,2019
Zuogui Pills inhibit mitochondria-dependent apoptosis of follicles in a rat model of premature ovarian failure Peng H, et al,/,2019
The Effects of Anacyclus pyrethrum Alcoholic Root Extract on FSH, LH, Testosterone and Sperm Count in Diabetic Male Rats Mohammad Reza Shahraki,/,2019
Umbilical Cord Mesenchymal Stem Cell Transplantation Prevents Chemotherapy-Induced Ovarian Failure via the NGF/TrkA Pathway in Rats Qun Zheng,/,2019
Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation Abdel-Magied N, et al,/,2019
Comparative Studies on Chemical Contents and Effect in Kidney-Yang Deficiency Rats of Salt-Processed Product and Wine-Processed Product of Cuscutae Semen Ying Zhang, et al,/,2019
Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile inflammatory and hormonal parameters and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats N Mirfakhraie,/,2024
Dietary Supplements of Barley and Date-Palm Fruit Improved the Growth Defects of Ovaries of Rat Offspring Maternally Fed on Hypercholesterolemic Diet Hassan I. H. El-Sayyad, et al,/,2019
Crotonaldehyde-induced alterations in testicular enzyme function and hormone levels, and apoptosis in the testes of male Wistar rats are associated with oxidative damage Zhang B, et al,/,2019
Abnormal expression of HSP70 may contribute to PCOS pathology Wu G, et al,/,2019
The Effect of Hydroalchoholic Extract of Cinnamon zeylanicum on Oxidative Damages and Biochemical Change in Adult Rats With Polycystic Ovary Syndrome Khodaeifar F, et al,/,2019
Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its anti-inflammatory and anti-oxidant activities Jong Hee Choi, et al,/,2019
Traditional Medicine (Mahuang-Tang) Improves Ovarian Dysfunction and the Regulation of Steroidogenic Genes in Letrozole-Induced PCOS Rats Yang H, et al,/,2019
PROTECTIVE EFFECTS OF CACTUS AND/OR PAPAYA JUICES AGAINST HEPATIC AND TESTICULAR TOXICITY INDUCED BY CHLORPYRIFOS IN ALBINO RATS Mogahed H E, et al,/,2019
THE IMPACT OF 2-AMINOETHANESULFONIC ACID, GUARANINE METHYL THEOBROMINE 1, 3, 7-TRIMETHYLXANTHINE THEINE AND/OR ISOBUTYLPHENYL PROPIONIC ACID ON MASCULINE FECUNDITY, AND MORPHOPATHOLOGICAL DISORDERS IN RATS DAYYIH W A B U, et al,/,2019
Mutant screen for reproduction unveils depression-associated Piccolo's control over reproductive behavior Gerardo A,/,2020
Effects of leptin on HPG axis and reproductive function in male rat in simulated altitude of 5500 m hypoxia environment X Liu,/,2020
Effect of Iron Oxide Nanopartical on The FSH, LH and Testesteron Hormones in The offspring of Albino Rats RH Kamel,/,2020
CUMS Promotes the Development of Premature Ovarian Insufficiency Mediated by Nerve Growth Factor and Its Receptor in Rats X Fu,/,2020
The protective role of l-carnitine on spermatogenesis after cisplatin treatment during prepubertal period in rats: A pathophysiological study AM Aboul-Naga,/,2020
D-ribose-L-cysteine improves hormonal imbalance, spermatogenic dysregulation, and redox status in streptozotocin-diabetic rats VO Ukwenya,/,2020
Effect of Vitex Agnus-Castus Ethanolic Extract on Sex Hormones in Streptozotocin-Induced Diabetic Rats F Soleymanzadeh,/,2020
Effects of Coenzyme Q10 on Ovarian Surface Epithelium-derived Ovarian Stem Cells and Ovarian Function in 4-vinylcyclohexene Diepoxide-induced Ovarian Failure Mice Hyun Joo Lee,/,2021
Impact of Curcumin on Ovarian Reserve After Tubal Ligation: an Experimental Study GD Isgoren,/,2021
Protective Effect of Hydroalcoholic Extract of Orange Peel on PCNA and FSH-R Gene Expression in Histological Damage and Oxidative Stress Due to Ovarian Torsion in Adult Rats SRT Nejad,/,2021
Umbelliferone ameliorates oxidative stress and testicular injury, improves steroidogenesis and upregulates peroxisome proliferator-activated receptor gamma in type 2 diabetic rats MAM Allam,/,2021
Thymol alleviates imidacloprid-induced testicular toxicity by modulating oxidative stress and expression of steroidogenesis and apoptosis-related genes in adult male rats TM Saber,/,2021
Effect of Omega-3 or Omega-6 Dietary Supplementation on Testicular Steroidogenesis, Adipokine Network, Cytokines, and Oxidative Stress in Adult Male Rats A Moustafa,/,2021
Quercetin and vitamin E attenuate diabetes‐induced testicular anomaly in Wistar rats via the mitochondrial‐mediated apoptotic pathway OO Ojo,/,2021
l-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity NF Khedr,/,2021
l-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity NF Khedr,/,2021
Long Term Sodium Nitrate Administration Positively Impacts Metabolic and Obesity Indices in Ovariectomized Rats N Yousefzadeh,/,2021
Effects of Rosa damascena on reproductive improvement, metabolic parameters, liver function and insulin-like growth factor-1 gene expression in estradiol valerate induced polycystic ovarian syndrome in Wistar rats RM Salama,/,2022
Adverse effects of aspirin on hormonal and hastopathlogical changes in male rats IQ Naji,/,2022
Effects of sea salt intake on metabolites, steroid hormones, and gut microbiota in rats S Chanmuang,/,2022
Assessment toxic effects of exposure to 3-indoleacetic acid via hemato-biochemical, hormonal, and histopathological screening in rats HTH Ismail - Environmental Science and Pollution Research,/,2022
Mechanistic insights into the protective role of eugenol against stress-induced reproductive dysfunction in female rat model H Helmy,/,2022
The effects of fenugreek (trigonella foenum-graecum), sesame (sesamum indicum) and domperidone on weights and some hormones of lactating white female ra IH Ali,/,2022
Reprotoxicological Ameliorating Effect of Camel Milk against Aflatoxicosis in Male Rats BJ Mohammad,/,2022
Olive Leaf Extract Attenuates Chlorpyrifos-Induced Neuro-and Reproductive Toxicity in Male Albino Rats AA Hassan,/,2022
Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation H Rakhshandeh,/,2022
EFFECT OF POLYETHYLENE TEREPHTHALATE AS POLLUTANT OF DRINKING WATER ON SOME PHYSIOLOGICAL PARAMETERS IN MALE RATS AST Dawood,/,2022
Effect of Ethanol Extract of Red Beetroot (Beta vulgaris L.) on the Follicle Stimulating Hormone Levels among Wistar Rats (Rattus norvegicus) Exposed to Cigarette Smoke SH Nur,/,2022
Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats A Al-Shahat,/,2022
Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue HM Rabah,/,2023
Egyptian Journal of Plant Protection Research Institute AK Randa,/,2023
Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats MU Ijaz,/,2023
Absorbable protein stent for vasovasostomy in a rat model H Zhang,/,2023
17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomy Y Tian,/,2023
Long-term Ovariectomy Reduces Tolerance of Rats to Myocardial Ischemia-reperfusion Injury N Yousefzadeh,/,2023
Oxidative and Inflammatory Disruptions of Hypothalamic-Pituitary-Testicular Axis by Octylphenol and Protective Role of Alpha Lipoic Acid: Histological and Biochemical Studies EA Awadalla,/,2023
Rapamycin Induced Autophagy in Mesenchymal Stem Cells Modulates Cell Survival After Transplantation in a Rat Model with Cisplatin-Induced Ovarian Toxicity via Deactivation of the mTOR Pathway A Sarhan,/,2023
Altered m6A modification is involved YAP-mediated apoptosis response in 4-vinylcyclohexene diepoxide induced ovotoxicity Y Li,/,2023
Ameliorative potential of the quercetin on lead-induced testicular damage: morphohistometric and biochemical analysis HN Mustafa - African Journal of Urology,/,2023
Protective Effects of Echinacea (Echinacea purpurea L.) and Chamomile (Matricariachamomilla L.)Extracts on Sex Hormonal Disturbances and Immune Response Induced by Calcium Carbide in Male Rats S Ismail,/,2023
The anti-androgenic effect of quercetin on hyperandrogenism and ovarian dysfunction induced in a dehydroepiandrosterone rat model of polycystic ovary syndrome AA Mahmoud,/,2023
Zuogui pills maintain the stemness of oogonial stem cells and alleviate cyclophosphamide-induced ovarian aging through Notch signaling pathway L Zeng,/,2023
Constant light exposure alters gut microbiota and short‐/medium‐chain fatty acids and aggravates PCOS‐like traits in HFD‐fed rats F Yue,/,2023
Studies on the anti-aging properties of bovine whey supplementation on reproductive hormonal profiles and sperm structure and function of adult and senile rats NTAH Kandil,/,2023
The combination of ginger and zinc supplement could improve lead-induced reproductive dysfunction by inhibiting apoptosis mediated by oxidative damage and inflammation W Xue,/,2023
Role of glandular hormones in estimating time passed since death: histological and biochemical examination (an experimental study) A Gamal Ramadan,/,2023
Seasonal expressions of the translocator protein (18 kDa), voltage-dependent anion channel, and steroidogenic acute regulatory protein in the scent glands of muskrats (Ondatra zibethicus) W Xie,/,2023
Cuphea Ignea Extract Relieved the Histological Changes and Activated the NF-ҠB Protein of Female Reproductive Organs and Stomach in EtOH-Treated Rats AENA Madbolia,/,2023
Participación del factor inhibitorio de leucemia en los niveles de acetilcolina y en la foliculogénesis ovárica en rata SI Peña Díaz,/,2023
Antioxidant, anti-inflammatory, and anti-apoptotic effects of genkwanin against aflatoxin B1-induced testicular toxicity MU Ijaz,/,2023
Chronic Fluoride Exposure Induces Ovarian Dysfunction and Potential Association with Premature Ovarian Failure in Female Rats X Tang,/,2023
Syzygium malaccense leaves methanol extract modulate some biochemical and inflammatory markers and prostate histology of testosterone-estradiol valerate induced benign prostatic hyperplasia in rats NK Achi,/,2023
The role of the indoleamine 2, 3-dioxygenase gene in preventing ovarian transplant rejection in rats A Long,/,2024
Influence of prepubertal aflatoxicosis on pubertal reproductive activity in male rats HH Al,/,2024
Effect of long-term inorganic nitrate administration on myocardial ischemia-reperfusion injury in ovariectomized rats S Jeddi,/,2024
Mitigation of letrozole induced polycystic ovarian syndrome associated inflammatory response and endocrinal dysfunction by Vitex negundo seeds TK Kar,/,2024
Zhibai Dihuang pill (ZBDH) exhibits therapeutic effects on idiopathic central sexual precocity in rats by modulating the Gut Microflora C Yi,/,2024
Correlations between beclin-1 and transforming growth factor-β1 in letrozole induced polycystic ovary syndrome N Hamdy,/,2024
Promising drug candidates for the treatment of polycystic ovary syndrome (PCOS) as alternatives to the classical medication metformin HS Anbar,/,2023
Assessment of Cinnamaldehyde's Potency on Heat Stress-induced Testicular Impairments in Wistar Rats P Muthusamy,/,2024
Impacts of Echinacea purpurea on the immune-reproductive changes associated with the aging process in male rats KH Mohamed,/,/
Comparison of the therapeutic effect of platelet-rich plasma and injectable platelet-rich fibrin on testicular torsion/detorsion injury in rats EFM Eisa, SAM Ezzeldein, HA Mohammed,/,2024
Echis ocellatus venom-induced sperm functional deficits, pro-apoptotic and inflammatory activities in male reproductive organs in rats: antagonistic role of kaempferol BS Ajisebiola, AA Toromade, JO Oladele,/,2024
Bone marrow mesenchymal stem cells expressing Neat-1, Hotair-1, miR-21, miR-644, and miR-144 subsided cyclophosphamide-induced ovarian insufficiency by remodeling the IGF-1–kisspeptin system, ovarian apoptosis, and angiogenesis AI Ahmed, MF Dowidar, AF Negm, H Abdellatif,/,2024
Ameliorative Effect of Chitosan/Spirulina platensis Ethanolic Extract Nanoformulation against Cyclophosphamide-Induced Ovarian Toxicity: Role of PPAR-γ/Nrf-2/HO-1 and NF-kB/TNF-α Signaling Pathways M Almukainzi, TA El-Masry, HA Ibrahim, HM Saad,/,2024
Effect of Iraqi Apricot Seed Extract on Some Physiological Parameters in Male Rats NSK Mohammad, AH Ali,/,2024
The ameliorative effects of bee bread supplement on the ovarian dysfunction induced by high-fat diet: Comparison with S. officinalis and shifting to normal diet supplement GM Ezzat, MF Ali, HAA Hussein,/,2024
Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium Ameliorates Diabetes-Induced Testicular Damage and Sperm Abnormalities by Mitigating Oxidative Stress, Apoptosis, and Inflammation M Sargazi, N Karbalaei, S Karbalay-Doust,/,2024
MSCs–derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis NM Elsherbiny, MS Abdel-Maksoud, K Prabahar,/,2024
The therapeutic effects of curcumin on polycystic ovary syndrome by upregulating PPAR-γ expression and reducing oxidative stress in a rat model W Zhang, C Peng, L Xu, Y Zhao, C Huang,/,2024
Hydrogen sulfide repairs testicular damage induced by heat stress in rats X Guo, Y Yin, S Guo, X Chen, S Xie, S Chen,/,2025
Cinnamon zeylanicum extract improves some metabolic disorders associated with polycystic ovary syndrome by modulating miR-21/SIRT-1/GSK-3β pathways EA El-komy, AD Abd El-Magid,/,2025
Exploring the protective effects of ethanolic extract of Chenopodium quinoa seed (quinoa) on the reproductive alterations of BPA-exposed females in vivo: a preliminary study PK Jana, S Sil, A Ghosh, I Sultana,/,2025
Pachymic acid ameliorates polycystic ovary syndrome via inactivating Akt/ERK signaling D Ji, C Zhang, F Fang, Y Yi,/,/
The Ameliorative Effects of Broccoli Extract on Lead-Induced Reproductive Toxicity and DNA Damage in Pre-Pubertal Rats V Nithya, J Radhika, P Murali,/,2025
Impact of variations in oral and intraperitoneal administration of cyclophosphamide on testicular toxicity in adult male albino rats NM Samak, SA El-Saidy, GM El Khodary,/,2025
Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein Y Zeng, Y Yang, F Zeng, Q Feng,/,2025
The Ameliorative Effects of Probiotics on the Sperm Quality and Testicular Structure After Ischemia/Reperfusion Injury Following Testicular Torsion/Detorsion Z Akbari, N Karbalaei, S Karbalay-Doust,/,2025
Thymol alleviates silica dioxide nanoparticle-induced reproductive performance toxicity via antioxidant and anti-inflammatory mechanisms in male rats MA Khedr, AA Goma, RR Rashed, HG Tohamy,/,2025
Effectiveness of hesperidin and rutin on cisplatin-induced testicular dysfunction in rats DMI Heibashy, WA Morsy,/,2025
Effects of High-Dose Boric Acid on Hormonal Status, Oxidative Stress, and DNA Damage in Female Rats During the Menstrual Cycles HH DEMİREL, F KARABAĞ, DA ACAROZ, FZ NAVRUZ,/,2025
Kuntai Capsules Improve Premature Ovarian Failure by Regulating AMPK-Mediated Autophagy X Ye, M Chen, J Zhong, H Chen, X Lin,/,2025
Ameliorative effects of Brassica oleracea var. viridis ethanol extract and fractions on cimetidine-induced reproductive toxicity in male Wistar rats I EMMANUEL ORIRE, V Otu Oka,/,2025
Toxicological Impacts of Certain Herbicides on Reproductive System and Thyroid Gland in Male Rats NM Hussein,/,2025
Betaine alleviates letrozole-induced polycystic ovarian syndrome in rats by regulating oxidative stress and inflammation and restoring the proliferation-apoptosis balance E Babaeenezhad, D Farzane Yegane,/,2025
Endocrine and Metabolic Science AE Ogunmokunwa, BO Ibitoye,/,/

Target Background

Function(From Uniprot)

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.

Gene References into Functions

Study in primary rat pituitary cells demonstrates that miR-186-5p regulates FSH secretion by directly targeting the FSHb 3' UTR. PMID:29534107
our results indicate that miR-21-3p and miR-433 can down-regulate the expression of FSHb by directly targeting the FSHb 3'UTR in rat primary pituitary cells. PMID:28402262
the upstream region of Fshb is susceptible to unsaturated long-chain fatty acids PMID:26853521
GnRH stimulation of Fshb expression is dependent on miR-132/212 and involves a SIRT1-FOXO1 pathway. PMID:25635942
FSH acutely regulated CCND2 expression through both PKA and PI3K signaling pathways during granulosa cell proliferation and also accelerated its ubiquitination-proteasomal degradation. PMID:23349233
Data suggest that FSH (Cga/FSHb) induces clock system in granulosa cells by up-regulation of connexin 43 expression; this suggests that gap junctions are implicated in circadian clock in peripheral oscillators besides central pacemaker. PMID:23299500
Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model. PMID:22249524
FSH autoantibody could cause the reduction of inhibin B, thereby inducing hypospermatogenesis via augment of spermatogenic cell apoptosis PMID:22564408
Novel findings supporting the role of FSH in primordial follicle survival through an action on apoptosis. PMID:22106407
These results show that the synthesis of FSH isoforms possessing alpha2,6-linked sialic acid is hormonally regulated in male rats. PMID:19464343
Data suggest that FSH beta subunit expression (and LH beta subunit expression) is regulated by DUSP1 expression (specifically in response to high-frequency GnRH pulses); this effect may occur in association with MAPK3/1 phosphorylation. PMID:21228211
A potential new regulatory mechanism of the FSH signalling pathway that could occur during maturation of testicular cells. PMID:20201104
Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. PMID:12145338
The regulation of FSHbeta is dependent on activin-mediated signaling factors in concert with pituitary-derived nuclear regulatory proteins. PMID:12554780
PACAP contributes to the selective regulation of FSHbeta expression during maturation in the male PMID:12646491
androgens acting directly on the pituitary increase FSH-beta and decrease LH-beta transcription. PMID:14512439
FSH enhances HIF-1 activity downstream of the PI 3-kinase/AKT/Rheb/mTOR pathway in GCs and HIF-1 activity is necessary for FSH to induce multiple follicular differentiation markers PMID:14982927
SMAD3 plays an important role in the synergistic effects of activin and gonadotropin-releasing hormone and demonstrate that this synergy is mediated by a palindromic cis-element located at -266/-259 of the rFSHbeta gene promoter PMID:15375186
Smad3 is not only sufficent but also necessary for activin-mediated regulation of FSHbeta promoter. PMID:15761025
oxidative stress induces apoptosis in preovulatory follicles and the antiapoptotic effect of FSH is mediated in part by stimulation of follicular GSH synthesis and suppression of ROS production PMID:16339198
Testosterone regulates FSHbeta transcription, in part, through modulation of various components of the activin-signaling system. PMID:17405825
The result found that pyramidal neurons from CA1 to CA4 region and granule neurons in dentate gyrus could express FSH and its receptor, majority of hippocampal neurons co-expressed FSH and its receptor, FSH and GnRH receptor. PMID:17674129
Smad3 and Pitx2 cooperate in stimulation of FSHbeta gene transcription. PMID:18022758
PI3-kinase may be involved in the negative regulation of alpha- and FSHbeta-subunit gene expression as well as cell proliferation. PMID:18206295
Dexamethasone (4 nM) for 3 weeks partially rescued LH beta/follicle-stimulating hormone beta cells. PMID:18363807