Recombinant Rat Complement factor I (Cfi)

E.coli
In Vivo Biotinylation in E.coli

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Cfi

Purity

>85% (SDS-PAGE)

Target Names

Cfi

Uniprot NO.

Q9WUW3

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

19-604

Target Protein Sequence

KN TPASGQPQED LVEQKCLLKN YTHHSCDKVF CQPWQKCIEG TCACKLPYQC PKAGTPVCAT NGRGYPTYCH LKSFECLHPE IKFSNNGTCT AEEKFNVSLI YGSTDTEGIV QVKLVDQDEK MFICKNSWST VEANVACFDL GFPLGVRDIQ GRFNIPVNHK INSTECLHVR CQGVETSLAE CTFTKKSSKA PHGLAGVVCY TQDADFPTSQ SFQCVNGKRI PQEKACDGVN DCGDQSDELC CKGCRGQAFL CKSGVCIPNQ RKCNGEVDCI TGEDESGCEE DKKNKIHKGL ARSDQGGETE IETEETEMLT PDMDTERKRI KSLLPKLSCG VKRNTHIRRK RVVGGKPAEM GDYPWQVAIK DGDRITCGGI YIGGCWILTA AHCVRPSRYR NYQVWTSLLD WLKPNSQLAV QGVSRVVVHE KYNGATYQND IALVEMKKHP GKKECELINS VPACVPWSPY LFQPNDRCII SGWGREKDNQ KVYSLRWGEV DLIGNCSRFY PGRYYEKEMQ CAGTSDGSID ACKGDSGGPL VCKDVNNVTY VWGIVSWGEN CGKPEFPGVY TRVASYFDWI SYYVGRPLVS QYNV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization.

Subcellular Location

Secreted, extracellular space.

Protein Families

Peptidase S1 family

Tissue Specificity

Expressed in the liver by hepatocytes. Also present in other cells such as monocytes, fibroblasts or keratinocytes.

Database Links

UNIGENE: Rn.7424

KEGG: rno:79126

STRING: 10116.ENSRNOP00000032881

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