Recombinant Rat Alpha-1-antiproteinase (Serpina1)

Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Serpina1

Uniprot NO.

P17475

Alternative Names

Serpina1Alpha-1-antiproteinase; Alpha-1-antitrypsin; Alpha-1-proteinase inhibitor; Serpin A1

Species

Rattus norvegicus (Rat)

Source

Baculovirus

Expression Region

25-411

Target Protein Sequence

EDAQET DTSQQDQSPT YRKISSNLAD FAFSLYRELV HQSNTSNIFF SPMSITTAFA MLSLGSKGDT RKQILEGLEF NLTQIPEADI HKAFHHLLQT LNRPDSELQL NTGNGLFVNK NLKLVEKFLE EVKNNYHSEA FSVNFADSEE AKKVINDYVE KGTQGKIVDL MKQLDEDTVF ALVNYIFFKG KWKRPFNPEH TRDADFHVDK STTVKVPMMN RLGMFDMHYC STLSSWVLMM DYLGNATAIF LLPDDGKMQH LEQTLTKDLI SRFLLNRQTR SAILYFPKLS ISGTYNLKTL LSSLGITRVF NNDADLSGIT EDAPLKLSQA VHKAVLTLDE RGTEAAGATV VEAVPMSLPP QVKFDHPFIF MIVESETQSP LFVGKVIDPT R
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin.

Gene References into Functions

A1AT bidirectional uptake and secretion from lung endothelial cells towards the alveolar epithelium and airspaces PMID:24743137
These results suggest that transfer of the N-terminal acidic extension of HCII to alpha1-PI M358R enhanced its inhibition of thrombin by conferring the ability to bind exosite 1 on HAPI M358R. PMID:16981704

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Subcellular Location

Secreted.

Protein Families

Serpin family

Tissue Specificity

Plasma.

Database Links

UNIGENE: Rn.1419

KEGG: rno:24648

STRING: 10116.ENSRNOP00000012577

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