Recombinant Pig Apolipoprotein A-I (APOA1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

APOA1

Uniprot NO.

P18648

Alternative Names

APOA1Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I; ProapoA-I); Truncated apolipoprotein A-I]

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

25-265

Target Protein Sequence

DDPQSP WDRVKDFATV YVDAIKDSGR DYVAQFEASA LGKHLNLKLL DNWDSLGSTF TKVREQLGPV TQEFWDNLEK ETEALRQEMS KDLEEVKKKV QPYLDDFQNK WQEEMETYRQ KMAPLGAEFR EGARQKVQEL QEKLSPLAEE LRDRLRAHVE ALRQHVAPYS DDLRQRMAAR FEALKEGGGS LAEYQAKAQE QLKALGEKAK PALEDLRQGL LPVLENLKVS ILAAIDEASK KLNAQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Gene References into Functions

Alterations in the Apo A-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A-I were observed in Salmonella typhimurium and Escherichia coli infections. PMID:25377528
blood level decreases during experimentally induced acute-phase processes in pigs PMID:15845530
down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 and tumor necrosis factor-alpha PMID:15878672

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Subcellular Location

Secreted.

Protein Families

Apolipoprotein A1/A4/E family

Tissue Specificity

Major protein of plasma HDL, also found in chylomicrons. Synthesized predominantly in the intestine and the liver.

Database Links

UNIGENE: Ssc.807

KEGG: ssc:397691

STRING: 9823.ENSSSCP00000015994

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