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Recombinant Pig Androgen receptor (AR), partial

Code
MSDS
MSDS Datasheet
Size Pls inquire
Source
Conjugate
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Product Details

Abbreviation
AR
Purity
>85% (SDS-PAGE)
Target Names
AR
Uniprot NO.
Alternative Names
AR; NR3C4Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
Species
Sus scrofa (Pig)
Source
Yeast
Expression Region
1-896
Target Protein Sequence
MEVQLGLGRV YPRPPSKTFR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GARLQQQQLQ QQETSPRRQQ QQQQQPSEDG SPQVQSRGPT GYLALDEKQQ PSQQQSAPEC HPESGCTPEP GAASAASKGL QQQPPAPPDE DDSAAPSTLS LLGPTFPGLS SCSTDLKDIL SEAGTMQLLQ QQQQQQQQQE AVSEGNSSGR AREATGAPIS SKDSYLGGSS TISDSAKELC KAVSVSMGLG VEALEHLSPG EQLRGDCMYA PLLTGPPSVR PTPCAPLAEC KGSLLDDGPG KSNEETAEYS PFKAGYTKGL DSESLGCSSG GEAGGSGTLE LPSALSLYKS GALDDVAAYP SRDYYNFPLA LAGPPPPPPP PHPHARIKLE NPLDYGSAWA AAAAQCRYGD LASLHGGGAP GPGSGSPSAT SSSSWHTLFT AEESQLYGPC GGGGGGSAGE AGAVAPYGYT RPPQGLAGQE GDLAIPDIWY PGGVVSRVPY PSPSCVKSEM GPWMESYSGP YGDMRLEPTR DHVLPIDYYF PPQKTCLICG DEASGCHYGA LTCGSCKVFF KRAAEGKQKY LCASRNDCTI DKFRRKNCPS CRLRKCYEAG MTLGARKLKK LGNLKLQEEG EASSATSPTE EPAQKLTVSH IEGYECQPIF LNVLEAIEPG VVCAGHDNNQ PDSFAALLSS LNELGERQLV HVVKWAKALP GFRNLHVDDQ MAVIQYSWMG LMVFAMGWRS FTNVNSRMLY FAPDLVFNEY RMHKSRMYSQ CVRMRHLSQE FGWLQITPQE FLCMKALLLF SIIPVDGLKN QKFFDELRMN YIKELDRIIA CKRKNPTSCS RRFYQLTKLL DSVQPIAREL HQFTFDLLIK SHMVSVDFPE MMAEIISVQV PKILSGKVKP IYFHTQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Partial
Tag Info
N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Condition
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Gene References into Functions
  1. In GD20 and PD2 males we found the reduction of the luminal compartment, inflammatory changes, decreased androgen receptor and increased Cx43 expression PMID:24151599
  2. Data suggest that signal transduction involving androgen receptor is involved in apoptosis of granulosa cells (as seen in follicular atresia). PMID:22522230
  3. AR is a potential candidate gene for traits related to pig reproduction and performance PMID:15157735
  4. presence of AR during gestation in non-gonadal tissues suggests a role of androgen in these tissues PMID:17482664
  5. Pig ejaculated spermatozoa express androgen receptor. PMID:17553131

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
Nuclear hormone receptor family, NR3 subfamily
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