Recombinant Mouse Vitamin K-dependent protein C (Proc)

1. Data show that activated protein C signals via protease activated receptors PAR2/PAR3 to expand Treg cells, mitigating the disease in mice. PMID:28827518
2. APC modifies pulmonary fibrosis by limiting thrombin-dependent macrophage recruitment. PMID:27295971
3. Small interfering RNA-mediated silencing of protein C in apolipoprotein E-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis. PMID:28302625
4. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC in the context of endotoxemia and infection PMID:26341257
5. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow. PMID:26457757
6. impaired EPCR/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis PMID:26045607
7. SOD prevents thrombomodulin methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice. PMID:26069236
8. sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation. PMID:25069533
9. Data identify anticoagulant activated protein C as a "metaplastic molecule", capable of shifting the threshold of LTP towards further potentiation PMID:24753100
10. Histones regulate activated protein C formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis. PMID:24177324
11. EPCR and APC play a limited role in the host response during pulmonary tuberculosis. PMID:23348224
12. Inhibition of the anticoagulant function of activated protein C does not interfere with its protective role during Gram-negative pneumosepsis, suggesting a more prominent role for cytoprotective effects of APC . PMID:23216621
13. RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis. PMID:23550037
14. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. PMID:23267072
15. Polyphosphate can elicit potent pro-inflammatory responses through the activation of NF-kappaB, which are counteracted by activated protein C. PMID:22372856
16. The aPC mechanism of action is complex, involving induction of Treg differentiation, inhibition of inflammation, and possibly direct cyto-protective effects on beta cells. PMID:22447930
17. We conclude that activated protein C generation and function can be modulated by changes in phospholipid occupancy of its endothelial cell receptor. PMID:22167755
18. Findings show that the protein C (PC) pathway is a unique system involved in controlling intestinal homeostasis and inflammation by regulating epithelial barrier function. PMID:22109555
19. Endogenous PC has strong effects on the host response to lethal influenza A infection, inhibiting pulmonary coagulopathy and inflammation on the one hand, but facilitating neutrophil influx and protein leak and accelerating mortality on the other hand. PMID:21330465
20. Endogenous protein C inhibits activation of coagulation and transiently lowers bacterial outgrowth in murine Escherichia coli peritonitis PMID:21251201
21. endogenous APC is essential for immune-mediated cancer cell elimination PMID:21420234
22. Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. PMID:20348393
23. endogenous acute coagulopathy is mediated by the activation of the protein C pathway PMID:19333141
24. These findings show a new function for the thrombomodulin-protein C system in controlling the growth and survival of trophoblast cells in the placenta, which is essential for the maintenance of pregnancy. PMID:12579195
25. surviving Thrombomodulin pro/pro mice displayed increased lung inflammation accompanied by higher mycobacterial loads in liver and spleen PMID:16014564
26. directly links host endogenous levels of PC with various coagulation, inflammation, and hemodynamic end points following a severe acute inflammatory challenge PMID:17047151
27. in the presence of a limited level of the anticoagulant, PC, placental homeostasis can be restored by reducing TF expression, thus facilitating proper embryonic implantation PMID:18647222
28. species specificity in the effects of pregnancy on the major determinants of the protein C system; Pregnancy causes a decrease in APC resistance in mice, which can be explained by the elevation of protein S levels and increased TFPI activity in plasma. PMID:19036061
29. An important role for the aPC/EPCR pathway in reducing metastasis via inhibition of tumor cell adhesion and transmigration. PMID:19188668
30. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. PMID:19350118
31. activated PC is barrier-protective in ventilator lung injury and endothelial PC receptor is a critical participant in APC-mediated protection PMID:19363121

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UNIGENE: Mm.2786

KEGG: mmu:19123

STRING: 10090.ENSMUSP00000132226