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Recombinant Mouse Relaxin receptor 1 (Rxfp1), partial

Recombinant Mouse Relaxin receptor 1 (Rxfp1), partial

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Source
Conjugate
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Target Background

Product Details

Abbreviation

Rxfp1

Purity

>85% (SDS-PAGE)

Target Names

Rxfp1

Uniprot NO.

Q6R6I7

Alternative Names

Rxfp1; Gm1018; Lgr7; Relaxin receptor 1; Leucine-rich repeat-containing G-protein coupled receptor 7; Relaxin family peptide receptor 1

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.

Gene References into Functions

No differences were found in RXFP1 expression related to aging. PMID:26109313
Colonic tissue expresses RXFP1 in smooth muscle cells of the muscular wall and in neurons of the myenteric plexus. PMID:26360621
relaxin/RXFP1 signaling in smooth muscle cells is important for normal collagen turnover and relaxation of the pubic symphysis during pregnancy PMID:25715795
maternal exposure to simazine causes disturbed relaxin signaling pathway and testicular dysfunction PMID:22984576
H3 relaxin exerts antifibrotic actions via RXFP1 receptor PMID:21229994
The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 tumors. PMID:20861284
Rxfp1 acts in an autocrine and/or paracrine fashion upstream of PCDHY in regulating increased canonical Wnt signaling in prostate cancer. PMID:20503398
mouse and rat LGR7 are the relaxin receptors in these species PMID:15566402
Mouse and rat LGR7 were able to bind to and be activated by relaxin ligands PMID:15956680
LGR7-Truncate is potentially an endogenous regulator of LGR7 signaling PMID:15956683
gene expression profiling of Lgr7 in the adult mouse brain PMID:15956708
expression of lgr7 in mouse brain membranes and neurons PMID:15956710
Inhibition of androgen-independent growth was also achieved by blocking expression of LGR7, the cognate receptor of H2 relaxin PMID:16434975
LGR7-expressing cells in the stroma are both necessary and sufficient for relaxin to promote proliferation and inhibit apoptosis in both stromal and epithelial cells of cervix and vagina. PMID:18218691
RXFP1 is involved in mediating relaxin's effects on airway fibrosis during homeostasis but not during inflammation-induced fibrosis associated with chronic allergic airways disease. PMID:18974264
Data show that cardiac RXFP1 expression increased in hearts of transgenic mice with cardiomyocyte-restricted overexpression of alpha1A-AR, alpha1B-AR, or beta2-AR, demonstrating distinct regulation by adrenergic signaling of cardiac RXFP1 expression PMID:19416204