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Recombinant Mouse Melanoma-associated antigen D1 (Maged1)

Recombinant Mouse Melanoma-associated antigen D1 (Maged1)

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Source
Conjugate
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Target Background

Product Details

Abbreviation

Maged1

Purity

>85% (SDS-PAGE)

Target Names

Maged1

Uniprot NO.

Q9QYH6

Alternative Names

Maged1; Nrage; Melanoma-associated antigen D1; Dlxin-1; MAGE-D1 antigen; Neurotrophin receptor-interacting MAGE homolog

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-775

Target Protein Sequence

MAQKPDGGAG LRGFQAEASV EDSALLVQTL MEAIQISEAP PTSQATAAAS GPNASPQSSQ PPTANEKADT EVSAAAARPK TGFKAQNATT KGPNDYSQAR NAKEMPKNQS KAAFKSQNGT PKGPHAASDF SQAAPTGKSA KKSEMAFKGQ NSTKAGPGTT YNFPQSPSAN EMTNNQPKTA KAWNDTTKVP GADAQTQNVN QAKMADVGTS AGISEADGAA AQTSADGSQT QNVESRTIIR GKRTRKVNNL NVEENNSGDQ RRASLASGNW RSAPVPVTTQ QNPPGAPPNV VWQTPLAWQN PSGWQNQTAR QTPPAARQSP PARQTPSAWQ NPVAWQNPVI WPNPVIWQNP VIWPNPIVWP GPIVWPNPMA WQSTPGWQSP PSWQAPPSWQ SPQDWQGPPD WQVPPDWSMP PDWSFPSDWP FPPDWIPADW PIPPDWQNLR PSPNLRSSSN SRASQNQGPP QPRDVALLQE RANKLVKYLM LKDYTKVPIK RSEMLRDIIR EYTDVYPEII ERACFVLEKK FGIQLKEIDK EEHLYILIST PESLAGILGT TKDTPKLGLL LVILGIIFMN GNRATEAVLW EALRKMGLRP GVRHPLLGDL RKLLTYEFVK QKYLDYRRVP NSNPPEYEFL WGLRSYHETS KMKVLRFIAE VQKRDPRDWT AQFMEAADEA LDALDAAAAE AEARAEARNR MGIGDEAVSG PWSWDDIEFE LLTWDEEGDF GDPWSRIPFT FWARYHQNAR SRFPQAFTGP IIGPSGTATA NFAANFGAIG FFWVE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Gene References into Functions

Both transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation. PMID:28528976
MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model PMID:26272363
Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB). PMID:24700102
NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB signalling pathway. PMID:25736627
Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src-dependent manner that is negatively regulated by NRAGE. PMID:23142633
We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes PMID:22865874
Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD) PMID:23300464
the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT ubiquitylation. PMID:22457503
XIAP-TAB1-TAK1 complex is dependent on NRAGE for IKK-alpha/beta phosphorylation and NF-kappaB activation. PMID:21789165
MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1, Rev-erbalpha and E4bp4 expression through the Rev-Erbalpha/ROR responsive elements (RORE). PMID:20300063
NRAGE induces NF-kappaB activation and MIF expression in P19 cells PMID:20100315
MHD2 of NRAGE was not necessary for BMP-induced p38MAPK activation or caspase-mediated apoptosis. PMID:19937275
roles for NRAGE as a mediator of precursor apoptosis and a repressor of cell cycle progression in neural development PMID:12204258
receptor tyrosine kinase-like orphan receptor 2(Ror2) sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of Mhomeobox, msh-like 2(msx2) PMID:12754255
The expression pattern of Maged1 roughly summarizes that of Maged2 and Maged3 PMID:15162511
necdin and MAGE-D1 cooperate to modulate the function of Dlx/Msx homeodomain proteins in cellular differentiation PMID:15272023
Our results suggest that interaction of cytosolic PrP and NRAGE could affect neuronal viability. PMID:15911347
NRAGE as an integral component in bone morphogenetic proteins signaling and clarify its role during neural progenitor development PMID:16107717
NRAGE plays an important role in apoptotic-signaling in vivo. PMID:18772898
NRAGE might have multiple roles during renal branching morphogenesis through association with both the BMP and GDNF signaling pathways. PMID:19268530
The netrin receptor UNC5H1 induces apoptosis through and interaction with NRAGE. PMID:12598531

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Subcellular Location

Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.

Tissue Specificity

Ubiquitously expressed in many adult tissues, except for the spleen. Expressed in osteoblastic and chondrogenic cell lines and also during embryonic development.

Database Links

UNIGENE: Mm.27578

KEGG: mmu:94275

STRING: 10090.ENSMUSP00000026142

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