Maged1 Antibody

Code: CSB-PA234148

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Size:

100μl

US$297

Quantity:

Species Reactivity: Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB

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Target Background

Product Details

Uniprot NO.

Q9QYH6

Target Names

Maged1

Alternative Names

Maged1 antibody; Nrage antibody; Melanoma-associated antigen D1 antibody; Dlxin-1 antibody; MAGE-D1 antigen antibody; Neurotrophin receptor-interacting MAGE homolog antibody

Raised in

Rabbit

Species Reactivity

Mouse,Rat

Immunogen

Peptide with sequence C-EAEARAEARNRMGIGDE derived from Mouse Melanoma-associated antigen D1.

Immunogen Species

Mus musculus (Mouse)

Clonality

Polyclonal

Purification Method

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot analysis of extracts from PC12 cells using Melanoma-associated antigen D1 Antibody and the same antibody preincubated with blocking peptide.

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Target Background

Function(From Uniprot)

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Gene References into Functions

Both transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation. PMID:28528976
MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model PMID:26272363
Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB). PMID:24700102
NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB signalling pathway. PMID:25736627
Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src-dependent manner that is negatively regulated by NRAGE. PMID:23142633
We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes PMID:22865874
Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD) PMID:23300464
the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT ubiquitylation. PMID:22457503
XIAP-TAB1-TAK1 complex is dependent on NRAGE for IKK-alpha/beta phosphorylation and NF-kappaB activation. PMID:21789165
MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1, Rev-erbalpha and E4bp4 expression through the Rev-Erbalpha/ROR responsive elements (RORE). PMID:20300063
NRAGE induces NF-kappaB activation and MIF expression in P19 cells PMID:20100315
MHD2 of NRAGE was not necessary for BMP-induced p38MAPK activation or caspase-mediated apoptosis. PMID:19937275
roles for NRAGE as a mediator of precursor apoptosis and a repressor of cell cycle progression in neural development PMID:12204258
receptor tyrosine kinase-like orphan receptor 2(Ror2) sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of Mhomeobox, msh-like 2(msx2) PMID:12754255
The expression pattern of Maged1 roughly summarizes that of Maged2 and Maged3 PMID:15162511
necdin and MAGE-D1 cooperate to modulate the function of Dlx/Msx homeodomain proteins in cellular differentiation PMID:15272023
Our results suggest that interaction of cytosolic PrP and NRAGE could affect neuronal viability. PMID:15911347
NRAGE as an integral component in bone morphogenetic proteins signaling and clarify its role during neural progenitor development PMID:16107717
NRAGE plays an important role in apoptotic-signaling in vivo. PMID:18772898
NRAGE might have multiple roles during renal branching morphogenesis through association with both the BMP and GDNF signaling pathways. PMID:19268530
The netrin receptor UNC5H1 induces apoptosis through and interaction with NRAGE. PMID:12598531

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Subcellular Location

Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.

Tissue Specificity

Ubiquitously expressed in many adult tissues, except for the spleen. Expressed in osteoblastic and chondrogenic cell lines and also during embryonic development.

Database Links

UNIGENE: Mm.27578

KEGG: mmu:94275

STRING: 10090.ENSMUSP00000026142

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