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Recombinant Mouse Lysosomal Pro-X carboxypeptidase (Prcp)

Recombinant Mouse Lysosomal Pro-X carboxypeptidase (Prcp)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Prcp

Purity

>85% (SDS-PAGE)

Target Names

Prcp

Uniprot NO.

Q7TMR0

Alternative Names

Prcp; Lysosomal Pro-X carboxypeptidase; EC 3.4.16.2; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

44-491

Target Protein Sequence

RKYSVLY FEQKVDHFGF ADMRTFKQRY LVADKHWQRN GGSILFYTGN EGDIVWFCNN TGFMWDVAEE LKAMLVFAEH RYYGESLPFG QDSFKDSQHL NFLTSEQALA DFAELIRHLE KTIPGAQGQP VIAIGGSYGG MLAAWFRMKY PHIVVGALAA SAPIWQLDGM VPCGEFMKIV TNDFRKSGPY CSESIRKSWN VIDKLSGSGS GLQSLTNILH LCSPLTSEKI PTLKGWIAET WVNLAMVNYP YACNFLQPLP AWPIKEVCQY LKNPNVSDTV LLQNIFQALS VYYNYSGQAA CLNISQTTTS SLGSMGWSFQ ACTEMVMPFC TNGIDDMFEP FLWDLEKYSN DCFNQWGVKP RPHWMTTMYG GKNISSHSNI IFSNGELDPW SGGGVTRDIT DTLVAINIHD GAHHLDLRAH NAFDPSSVLL SRLLEVKHMK KWILDFYSNI Q
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Gene References into Functions

Prolylcarboxypeptidase (PRCP) converts AngII to Ang (1-7) but only at an acidic pH. Global PRCP deficiency causes heart and kidney alterations and a moderate rise in BP. PRCP is abundant in the kidney collecting tubules, where the prevailing pH is low. In collecting tubules, PRCP deficiency could result in impaired AngII degradation. Increased AngII at this nephron site stimulates Na reabsorption and increases BP. PMID:28160049
activity and expression in plasma and lung tissue stays unaffected in lung ischemia-reperfusion injury PMID:27437782
This study demonistrated that PRCP gene is broadly expressed in the brain. PMID:24161824
PRCP regulates cell growth, angiogenesis, and the response to vascular injury PMID:23744584
PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both standard chow diet and high-fat diet PMID:22454290
analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors PMID:22079761
This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin levels and increased energy expenditure were also found. PMID:22202165
Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis. PMID:21297000
PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels. PMID:19620781