Recombinant Mouse Lipopolysaccharide-binding protein (Lbp)

1. The LBP gene is a macrophage-specific LXR target that promotes foam cell survival and atherogenesis. PMID:24671012
2. LBP is a critical factor in the development of non-alcoholic fatty liver disease. PMID:27404046
3. LBP is a proinflammatory soluble adipokine that acts as a brake for adipogenesis, strengthening the negative effects of palmitate and LPS on adipocyte differentiation. PMID:26201685
4. Differential expression of LBP and TGFB1, along with other genes, in different mesenchymal stromal cells preparations, produces the variable responses to external stimuli. PMID:24664302
5. findings describe a novel role for LBP in normal hippocampal development and raise the possibility that some of the behavioral sequelae of early life stress are mediated by reduced expression of LBP during a critical period of neurodevelopment. PMID:21993208
6. The amino acid sequence for two mimic epitopes of the inflammatory site of LBP were determined to be WKAQKRFMKKSG and LKTRKLFWKYKD. PMID:20833181
7. LBP plays an important role in early alcohol-induced liver injury by enhancing LPS-induced signal transduction, most likely in Kupffer cells. PMID:11884468
8. LBP plays an important role in resistance to lethal Salmonella peritonitis (but not to oral or intravenous infection) by facilitating the role of neutrophils in mediating acute inflammation. PMID:12055258
9. role LBP plays in local pulmonary immune defenses to bacterial challenge PMID:12353926
10. In the case of intraperitoneal infection of LBP-deficient mice with Salmonella typhimurium, no local inflammatory response is evident, neutrophil influx is delayed, and the mice succumb to the infection. PMID:12370383
11. plays an essential role in the innate immune response to Gram-positive pneumococci PMID:12932360
12. Locally produced LBP is an essential component of an effective innate immune response to E. coli peritonitis. PMID:14638760
13. LBP is one of the critical molecules regulating the acute and chronic airway response to inhaled lipopolysaccharides (LPS). PMID:15356561
14. LBP knockout mice are protected from toxicity with a decrease in hepatic necrosis following acetaminophen challenge. This suggests a novel role for LBP in modulating acetaminophen-induced liver injury. PMID:15619225
15. LBP does not contribute to an effective host response in Mycobacterium tuberculosis infection in mice. PMID:15993364
16. LBP per se possesses a protective effect on acute necrotizing pancreatitis PMID:16163057
17. In conclusion, hemorrhagic shock and resuscitation to mice cause severe, LBP-mediated hepatocellular damage. PMID:16614372
18. Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition. PMID:18559343
19. LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction. PMID:18948440
20. Marked concomitant increases in plasma LBP and endotoxin-like activity following murine trypanosome infection might play an important role in the pathogenesis of trypanosomosis PMID:19022463
21. Paneth cells express LBP together with other proteins acting in the innate immune response of the gut, such as lysozyme, defensins and intelectin. PMID:19234712
22. Innate defense against lethal peritoneal infection with Salmonella requires the direct proinflammatory involvement of LPS-binding protein (LBP), a major nonredundant function of LBP in this model. PMID:11466385

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UNIGENE: Mm.218846

KEGG: mmu:16803

STRING: 10090.ENSMUSP00000016168