Recombinant Mouse Isocitrate dehydrogenase [NADP] cytoplasmic (Idh1)

1. Vitamin C treatment induced an IDH1(R132H)-dependent reduction in cell proliferation. PMID:28663574
2. IDH1 expression regulates TCA cycle in glioma and affects glioma cell growth.GDH2 promotes growth of IDH1-expressing gliomas. PMID:29097607
3. Through the use of a conditional mutant mouse model that confers a less aggressive tumor phenotype, findings provide new insight into the effects of mutant Idh1 on a candidate cell of origin for glioma, mutant Idh1's role in disrupting the microenvironment from which gliomas arise, and mutant Idh1's effect on the course of glioma progression. PMID:28148827
4. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system. PMID:28465358
5. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis PMID:27693047
6. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1, enzymes involved in the TCA cycle, were elevated. PMID:27380194
7. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells PMID:26787889
8. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. PMID:25882048
9. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H. PMID:25849072
10. MiR-181a regulates lipid metabolism via IDH1 PMID:25739786
11. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity. PMID:25218477
12. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas. PMID:25730874
13. WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation. PMID:23107437
14. Brain-specific Idh1-KI mice show brain hemorrhage accompanied by high D2HG levels but decreased ROS PMID:22925884
15. Suggest that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes. PMID:22264756
16. Absence of IDH1 mutations in low-grade gliomas (LGGs) identifies a novel entity of LGGs with distinctive location, infiltrative behavior, specific molecular alterations, and dismal outcome. PMID:21080178
17. a possible association between IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. PMID:20861910
18. IDPc would be a major NADPH producer required for fat and cholesterol synthesis. PMID:15254034
19. The results suggest that IDPc plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen. PMID:17646934
20. IDPc is expressed differentially along tubules in patterns that may contribute to differences in susceptibility to injury, major enzyme in cytosolic NADPH generation in kidney, downregulated with ischemia-reperfusion PMID:19106211

Show More

Hide All

UNIGENE: Mm.9925

KEGG: mmu:15926

STRING: 10090.ENSMUSP00000095316