Recombinant Mouse Interleukin-19 (Il19)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Il19

Purity

>85% (SDS-PAGE)

Target Names

Il19

Uniprot NO.

Q8CJ70

Alternative Names

Il19Interleukin-19; IL-19

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

25-176

Target Protein Sequence

LRRCLI SVDMRLIEKS FHEIKRAMQT KDTFKNVTIL SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL RRISSIANSF LCVQKSLERC QVHRQCNCSQ EATNATRIIH DNYNQLEVSS AALKSLGELN ILLAWIDRNH LETPAA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis.

Gene References into Functions

Data, including data from studies using knockout mice, suggest that interleukin-19 suppresses hapten-dependent skin inflammation in elicitation phase of contact hypersensitivity. PMID:29386478
Attenuated colitis in IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. Microbial-driven expression of IL-19 by intestinal macrophages may contribute to the pathogenesis of inflammatory bowel disease. PMID:28864472
IL-19 can promote angiogenesis in the absence of hypoxia by at least two distinct mechanisms: 1) direct effects on vascular cells and 2) indirect effects by stimulation of macrophages. PMID:27053520
IL-19 plays an anti-inflammatory role in the Th2-mediated colitis model. PMID:27942772
microglia may self-limit their inflammatory response by producing the negative regulator IL-19. PMID:25794104
Lack of IL-19 exacerbates intimal hyperplasia PMID:24814101
we delineate the detailed molecular pathway for IL-4 up-regulation of IL-19 in keratinocytes, which may play an important role in AD pathogenesis. PMID:24943510
Il-19 expression is increased in astrocytes following bacterial challenge. PMID:24677051
IL-19 is important for cutaneous wound healing because it upregulates KGF expression. PMID:23582717
IL-19 is a potent inhibitor of experimental atherosclerosis. PMID:23950143
IL-19 is pivotal in the pathogenesis of breast cancer. PMID:22186257
endogenous IL-19 is a constituent of the regulome that controls both processes in vivo PMID:22110701
IL-19 drives pathogenic innate immune responses in the colon. PMID:19834971
In a dust mite-induced murine model of asthma, the IL-19 level in asthmatic BALB/cJ mice is twice that of healthy control mice. PMID:15557163