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Recombinant Mouse Complement component C8 gamma chain (C8g)

Recombinant Mouse Complement component C8 gamma chain (C8g)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

C8g

Purity

>85% (SDS-PAGE)

Target Names

C8g

Uniprot NO.

Q8VCG4

Alternative Names

C8gComplement component C8 gamma chain

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

21-202

Target Protein Sequence

QRTRKPIGST SPISTIQAQV NFSAQKFAGT WLLVAVGSSC RFLQEQGHRA EATTLHAAPQ GAAMAVSTFR KLDGICWQVR QLFENTGVPG RFLFQVSRAR GPVHMVVAET DYQSFAILYL EQGRKLSVKL YVRSLPVNDS VLDVFERRVR EANLTEDQIL FFPKYGFCET ADQLHILNEV PR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Gene References into Functions

A review of the human C8 gamma ortholog. PMID:11058761
This is a study of the human C8 orthologs. Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module, low-density lipoprotein receptor class A module, and membrane attack complex/perforin domain of C8 beta. PMID:12220191
This is a study of the human orthologs of C8 alpha, beta, and gamma. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria. PMID:12413696
Results describe the crystal structure of the human ortholog C8 alpha MACPF domain disulfide-linked to C8 gamma (alphaMACPF-gamma) at 2.15 A resolution. PMID:18440555